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Archive: December 2019

Arkana Employee Spotlight: Daniel

Arkana Employee Spotlight, employees at Arkana Laboratories
Meet Daniel McPherson. Daniel joined our client development team in 2012, and he has become not only a valuable asset to our practice but also an all-around great person to know.  His colleagues describe him as incredibly caring, creative, curious and inquisitive, helpful, and annoyingly chipper in the mornings.  The staff at Arkana frequently see Daniel moving heavy things around the office. This is primarily because he has a servant's heart and is always willing to help, but his background as a certified strength and conditioning coach doesn't hurt either. That certification has allowed him to greatly influence and impact...

Fellowing Joel – Episode 12

Fellowing Joel, Arkana Laboratories, Renal Pathology, fellowship program
We caught up with Dr. Murphy this week to see what's been happening in his world. [video width="1920" height="1080" mp4="https://www.arkanalabs.com/wp-content/uploads/Episode-12.mp4"][/video]    

Twitter Poll (December 11, 2019)

Anti-GBM disease, twitter poll, arkana laboratories
Answer: D Anti-GBM disease presents with rapidly progressive glomerulonephritis (GN) with or without pulmonary hemorrhage. On biopsy typical disease displays bright polytypic linear GBM staining for IgG by immunofluorescence and diffuse crescentic/necrotizing GN on light microscopy. Anti-glomerular basement membrane (GBM) nephritis is clinically and pathologically one of the most aggressive form of glomerulonephritis. Patients typically present with nephritic syndrome and rapidly progressive acute kidney injury. Lung involvement in the form of alveolar hemorrhage occurs in 34% to 62% of patients. Anti-GBM disease is due to circulating autoantibodies directed against cryptic epitopes in the NC1 domain of the alpha-3 chain of...

Art of Medicine: Proliferative Glomerulonephritis

Proliferative Glomerulonephritis
The above painting shows endocapillary hypercellularity with mononuclear cells and neutrophils, as well as hyaline deposits within glomeruli.  Red blood cell casts are seen within focal tubular lumens, and the tubules are widely spaced due to interstitial edema and inflammation.  These findings can be seen within acute proliferative glomerulonephritis.  Other proliferative changes within glomeruli seen in acute proliferative glomerulonephritis include mesangial hypercellularity and crescent formation. The differential diagnosis for proliferative glomerulonephritis is broad and includes infection-associated glomerulonephritis including post-streptococcal glomerulonephritis, focal or diffuse lupus nephritis, shunt nephritis, cryoglobulinemic glomerulonephritis, hepatitis-associated glomerulonephritis, and IgA nephropathy (or Henoch-Schonlein purpura nephritis).   Other considerations...

Disease Week: Alport Syndrome

alport syndrome, disease week, arkana laboratories
Monday In 1927, Dr. Cecil Alport published a series on "hereditary familial congenital haemorrhagic nephritis" where he described its association with deafness and the gender differences in disease severity. https://www.ncbi.nlm.nih.gov/pubmed/20773074          Interestingly, Dr Alport initially believed the etiology of the disorder was an individual susceptibility to a toxin of an unknown organism, probably belonging to the streptococcal group. https://www.ncbi.nlm.nih.gov/pubmed/20773074   The pathogenesis of the disorder known as Alport syndrome remained unknown until early 1970's, when advances in electron microscopy allowed the identification of characteristic abnormalities in GBMs. https://www.ncbi.nlm.nih.gov/pubmed/4343992   Dr Curtis Atkin, who suffered from Alport syndrome...

Fellowing Joel – Episode 11

Fellowing Joel, Arkana Laboratories, Renal Pathology, fellowship program
He's back! This week we caught up with Dr. Murphy to see what he's been up to the past couple of weeks. [video width="1920" height="1080" mp4="https://www.arkanalabs.com/wp-content/uploads/Episode-11.mp4"][/video]    

Diagnose This (December 2, 2019)

Glomerular Basement Membrane, Diagnose This, Arkana Laboratories
What is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​  ...