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Archive: August 2020

A Big MYMP Landing!

Article
Dr. Sharma, Dr. Larsen, Dr. Caza, NELL1, renal research
After several weeks of flying around our office, the MYMP landed and was caught by Dr. Caza, Dr. Larsen, and Dr. Sharma! Their newest paper discusses NELL1 and how it is a target antigen in malignancy-associated membranous nephropathy. Read the paper: NELL1 is a target antigen in malignancy-associated membranous nephropathy Who will catch the MYMP next?
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Road To Renal with Dr. May

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Dr. Murphy, Road to Renal, Dr. May, Arkana Podcasts
Our new fellow, Dr. May, began recording her new podcast this morning and her first guest was Dr. Murphy. He wanted to "dress up" for the occasion. Stay tuned for the first episode of Road to Renal with Dr. Rebecca May!  
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Twitter Poll (August 19, 2020)

Article
collapsing FSGS, twitter poll, Arkana Laboratories
Answer: A, Collapsing FSGS   HIV-associated nephropathy classically demonstrates collapsing FSGS. Other features include increased proximal tubule protein resorption droplets, and microcystic tubular dilatation. While this disease has markedly diminished in the presence of highly active antiretroviral therapy (HAART), the rate is still high in areas of sub-Saharan Africa. Within the United States, approximately 90% of cases occur in African Americans and are associated with genetic mutations in the APOL1 gene (G1/G2 alleles). The typical presentation is that of nephrotic syndrome secondary to widespread foot process effacement seen by electron microscopy. Interestingly, the CD4 count has not shown to be...
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Back To School Donations

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donations, Arkana Labs, giving back, Martin Luther King Jr. Elementary
Jack and JP (along with their Aunt Denise) stopped by this morning to help pack up school donations that Arkana has collected over the past few weeks. All donations are being given to the Martin Luther King Jr. Elementary School.  To make a contribution, visit the Little Rock School District's official website.
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Diagnose This (August 17, 2020)

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Membranous Glomerulopathy, PLA2R, Diagnose This, renal pathology, Arkana Laboratories
What is your diagnosis for this patient with nephrotic syndrome?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​...
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Diagnose This (August 10, 2020)

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Tags: Collapsing GN, Nephrotic syndrome, APOL1, G1/G2, transplant, COVID-19, Diagnose This
What is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​  ...
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Twitter Poll (August 5, 2020)

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Nail-Patella syndrome, Twitter Poll, Arkana Laboratories
Answer: A, Autosomal recessive inheritance Nail-Patella syndrome is a rare autosomal dominant disease with an incidence of approximately 1/50,000. The majority of cases are due to a mutation in LMX1B located at chromosome 9q34.1. The gene is important in development as it encodes a transcription factor important in dorsoventral pattern limb development, proper development of the anterior eye, neuron development within the CNS, and podocyte differentiation and maintenance. The kidney pathology is rather non-specific and can show minimal glomerular changes to variable degrees of FSGS with thickened capillary loops. By EM, the classic finding is that of "Moth-eaten" glomerular basement...
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MYMP Alert!

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collapsing glomerulopathy, Caza and Larsen, COVID-19, MYMP, Arkana Labs
Our MYMP made a special appearance today! Dr. Caza and Dr. Larsen teamed up with Dr. Velez to discuss the re-emergence of collapsing glomerulopathy with COVID-19. Read the paper: COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19 Stay on the lookout for the next MYMP sighting!  
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Diagnose This (August 3, 2020)

Article
Fibrillary Glomerulopathy, Diagnose This!, Arkana Laboratories, pathology, nephropathology, renal pathology
What is your leading diagnosis when seeing this interesting IgG staining pattern by IF?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​...
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