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Archive: April 2021

Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Neuro Notes, Neuropathology
The patient is a male in his 7th decade who presents with left occipital hemorrhagic stroke. The patient has a history of a right frontotemporal stroke from which he made an excellent recovery. The patient lives in an assisted living facility and also has mild cognitive issues, which were not of certain to the patient or family. Resection specimen from the left occipital lesion (A) shows acute hemorrhage, reactive astrogliosis, and thickened intraparenchymal, as well as thickened leptomeningeal, blood vessel walls.  A few scattered senile plaques (diffuse and neuritic) are also observed in the background.  Aβ-amyloid deposition in the blood...

Twitter Poll (April 28, 2021)

Linear GBM Poll
  Answer: Linear GBM   Anti-GBM disease is classically characterized by bright linear staining with IgG by immunofluorescence. By light microscopy, anti-GBM disease typically demonstrates a diffuse necrotizing, crescentic glomerulonephritis. Occasionally, multinucleated giant cells may be seen within the glomerular crescents as well as periglomerular areas. The pathophysiology of the disease is most often due to an autoantibody to the noncollagenous 1 (NC1) domain of the alpha 3 chain of collagen IV, however occasionally antibodies to the NC1 domain of the alpha 5 chain may also be present. Of note, a major prognostic factor at the time of biopsy is...

Arkana at Florida Society of Nephrology

florida society of nephrology, fsn21, nephrologists, renal biopsy
Join Arkana Laboratories at the Florida Society of Nephrology meeting to discuss how we can improve your renal biopsy process! Typically, renal biopsies are performed in a hospital setting and then sent off to a reference lab for interpretation. Once the biopsy arrives, the preliminary results (light microscopy and immunofluorescence) tend to take a few days, and electron microscopy will take 1 week or more. However, when biopsies are sent to Arkana Laboratories, we provide light microscopy, immunofluorescence, and electron microscopy results the same day the renal biopsy arrives at our lab. The Florida Society of Nephrology is a statewide...

Myotonic Dystrophy Type 2

Myotonic Dystrophy Type 2
A 55-year-old male with Myotonic Dystrophy Type 2 (DM2).  Frozen sections of skeletal muscle stained with H&E show moderate to marked variation in muscle fiber size with scattered ringbinden (ring fibers), a few nuclear bag muscle fibers, and minimally increased muscle fibers with internalized nuclei (1).  Ultrastructural examination shows a ring fiber with disorientation of peripheral myofibrils running perpendicularly to the central myofibrils of the muscle fiber (2).  (Original magnifications: A. Hematoxylin and eosin (H&E)-stained frozen section of skeletal muscle, 100x; B. Electron microscopy, 1000x)   Using the images, match the diagnosis and genetic alteration in this common muscular dystrophy...