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Immunoprofile of Meningioma, WHO grade I, Fibrous Variant. Hematoxylin and eosin (H&E)-stained sections show a dural-based spindle cell lesion arranged in broad sweeping fascicles without atypical features, higher grade growth patterns, or tumor necrosis (Figure 1), and at higher power there is an exceedingly rare mitotic figure, far less than 1 mitotic figure per 10 high-power fields (Figure 2). Immunohistochemical (IHC) work-up demonstrated strong diffuse membranous staining with epithelial membrane antigen (EMA+) (Figure 3), and positive immunoreactivity for somatostatin receptor 2A (SSTR2+) (Figure 4). Original magnifications: A. H&E, 100x; B. H&E, 400x; C. EMA, 100x; and D. SSTR2, 200x. ...