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Archive: July 2021

Immuno-Profile of WHO Grade I Meningiomas

Hematoxylin and eosin (H&E)-stained sections with EMA+, SSTR2+, STAT6-
Immunoprofile of Meningioma, WHO grade I, Fibrous Variant.  Hematoxylin and eosin (H&E)-stained sections show a dural-based spindle cell lesion arranged in broad sweeping fascicles without atypical features, higher grade growth patterns, or tumor necrosis (Figure 1), and at higher power there is an exceedingly rare mitotic figure, far less than 1 mitotic figure per 10 high-power fields (Figure 2).  Immunohistochemical (IHC) work-up demonstrated strong diffuse membranous staining with epithelial membrane antigen (EMA+) (Figure 3), and positive immunoreactivity for somatostatin receptor 2A (SSTR2+) (Figure 4).  Original magnifications: A. H&E, 100x; B. H&E, 400x; C. EMA, 100x; and D. SSTR2, 200x.  ...

Saying Goodbye to Dr. Messias

Goodbye Dr. Messias
Today, we shared many memories, laughs, and lots of tears. As we say goodbye, we remember all of the good times spent together throughout the years. Know that no matter where you road takes you, your family will always be here. We wish you the best of luck, Dr. Messias!  

Episode 25: Keep Good Company

What's So Special About Renal Pathology, first impressions, Keep Good Company, Stick to Your Knowledge, Never Be Afraid To Ask Questions, Making Time, How to Build A Reputation, Doing the Best You Can, Know Who Is In the Audience, Expanding the Differential Diagnosis, Knowing What Is Normal, Answer the Question, Knowing What You Know, Looking At Every Component, gestalt diagnosis, going deep, examining all the material, Lumping or Splitting, Focus, Using Therapy to Guide a Diagnosis, knowing the therapy, Severity of Change, principles of pathology, representativeness, arkana labs, renal path
In this episode, Dr. Silva recalls a time when Dr. Heptinstall extensively critiqued one of the first chapters Dr. Silva had written for their book and was eventually reminded of why he was so tough. The moral of the story: Keep good company.  

Donations for Back to School

Donations to Booker T. Washington Elementary
Thanks, Principal Aleta Branch and Assistant Principal Hazel Harris for letting our staff stop by Booker T. Washington Elementary and drop off a few supplies. We hope you have a great school year!   To directly donate, visit https://www.lrsd.org/washington.

Ganglioglioma, BRAF V600E-Mutated

BRAF V600E
Young adult female with a ganglioglioma (GG) in the right temporal lobe. Figure 1 is an MRI Brain image in the T1 sequence post-contrast in the coronal plane, which demonstrates a ~4 cm multicystic mass in the medial right temporal lobe with a solid mural nodular component with heterogeneous enhancement of the solid portions and cystic rim. Calcifications are noted along with the septal and wall components (not well demonstrated in the image shown).  Figure 2 is a hematoxylin and eosin (H&E)-stained section of formalin-fixed paraffin-embedded (FFPE) tissue demonstrating a low-grade glioneuronal tumor containing a dysplastic ganglion cell with a...

Twitter Poll (July 21, 2021)

Cortex and Medulla, Banff criteria, renal transplant Banff classifications
  Which of the following is not a part of the Banff adequacy criteria for the evaluation of acute rejection in a kidney biopsy? A) At least 10 glomeruli B) Minimum 7 glomeruli C) At least 2 Arteries D) Cortex and medulla   Answer: D) Cortex and medulla Per the 2018 Banff reference guide for the evaluation of transplant biopsies, an adequate specimen is one that contains at least 10 glomeruli and at least 2 arteries. Additionally, the guidelines stipulate that there should be at least two cores or two separate areas of cortex in the same core in order...

Episode 24: Knowing Who Is In The Audience Part 5

What's So Special About Renal Pathology, first impressions, Keep Good Company, Stick to Your Knowledge, Never Be Afraid To Ask Questions, Making Time, How to Build A Reputation, Doing the Best You Can, Know Who Is In the Audience, Expanding the Differential Diagnosis, Knowing What Is Normal, Answer the Question, Knowing What You Know, Looking At Every Component, gestalt diagnosis, going deep, examining all the material, Lumping or Splitting, Focus, Using Therapy to Guide a Diagnosis, knowing the therapy, Severity of Change, principles of pathology, representativeness, arkana labs, renal path
Have you ever had a conversation with someone and suddenly realized they might know more about the subject than you think they do? In this episode, Dr. Silva describes how he explained IgA nephropathy to the father of IgA nephropathy, Jean Berger. It's always important to know who is in the audience.