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- Published: March 15, 2019
- By: Arkana Author
The above painting shows features of a proliferative glomerulonephritis. Endocapillary proliferation, crescent formation, and segmental sclerosis is shown. These findings can be seen in focal or diffuse lupus nephritis, but are not specific, as they can be identified in other proliferative glomerulonephritides, such as IgA nephropathy, infection-associated glomerulonephritis, and others. Immunofluorescence studies can help in distinguishing lupus nephritis from other forms of proliferative glomerulonephritis, as there is typically a "full house" pattern with expression of all 3 immunoglobulin heavy chains (IgA, IgM, IgG), and complement (C3, C1q), as shown below. Classification of lupus nephritis is through the International Society of...