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Diagnose This (February 22, 2021)

amyloidosis, Amyloid Spicules on Jones Silver Stain, amyloid spicules with eyelashes, renal pathology
What is your leading diagnosis when seeing this finding along the glomerular capillary loops?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​...

Twitter Poll (February 3, 2021)

SAP, Serum amyloid protein P, twitter poll, renal pathology, arkana laboratories
Answer: C) SAP Serum amyloid protein P (SAP) has been found to be a highly sensitive and specific marker for the diagnosis of Membranous-Like Glomerulopathy with Masked IgG Kappa Deposits. Of note, while these cases show light chain restriction by immunofluorescence, most patients do not have evidence of an underlying paraprotein. For further information about this interesting entity, please see the following references. References Larsen CP, Sharma SG, Caza TN, et al. Serum amyloid P deposition is a sensitive and specific feature of membranous-like glomerulopathy with masked IgG kappa deposits. Kidney Int 2020 Mar;97(3): 602-608. Larsen CP, et al. Membranous-like...

Diagnose This (January 25, 2021)

Asteroid Body, Sarcoidosis, renal pathology, arkana laboratories, pathology of the kidney
What is the name of the finding at the end of the arrow and what condition is it classically associated with?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​...

Twitter Poll (January 20, 2021)

Immunotactoid Glomerulopathy, Immunotactoid, renal pathology, arkana laboratories
Answer: A, Immunotactoid Immunotactoid Glomerulopathy is characterized by parallel microtubular deposits with lucent cores which are classically greater than 30 nm by electron microscopy. Both fibrillary and amyloid fibrils are typically characterized as non-branching randomly oriented fibrils which range usually between 10-20 nm and 7-12 nm, respectively. Light chain deposition disease classically shows characteristic punctate, powdery deposits within glomeruli and tubular basement membranes by electron microscopy.  

Diagnose This (January 19, 2021)

Infection-Associated Glomerulonephritis, diagnose this, arkana laboratories, renal disease of the kidney
Based on the electron microscopic image, what would be your initial underlying clinical concern for the findings seen?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​...

Diagnose This (January 12, 2021)

antibody-mediated rejection, arkana laboratories, renal pathology, diagnose this, kidney disease
What are the two major changes seen in this image from an allograft kidney and what are these findings concerning for?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​...

Twitter Poll (January 6, 2021)

nodular glomerulosclerosis, renal pathology, arkana laboratories, kidney disease
Answer: D, All of the above All of the answer choices should be included in your differential diagnosis of a nodular glomerulosclerosis by light microscopy. Of note, idiopathic nodular glomerulosclerosis is typically associated with underlying hypertension and/or smoking.  

Diagnose This (January 4, 2021)

artery with a cholesterol embolus, arkana laboratories, renal pathology, renal disease
What is your diagnosis and what are some possible precipitating events that may lead to this finding?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​  ...

Twitter Poll (December 23, 2020)

anti-brush border antibody disease, ABBA, renal pathology, Twitter Poll, arkana labs
Answer: D The histologic features of a thrombotic microangiopathy (TMA) are non-specific as to etiology and include both acute and chronic changes. Acute changes of TMA include glomeruli demonstrating mesangiolysis, endothelial swelling, as well as intracapillary fibrin thrombi, and fragmented red blood cells. Blood vessels in the acute phase will also classically show endothelial swelling along with intimal mucoid edema and entrapped schistocytes. Chronic TMA changes include glomerular basement duplication with double contour formation and arterial/arteriolar intimal fibrosis with concentric lamination (onion skinning), to name a few. All of the above are known to lead to TMA except for anti-brush...

Diagnose This (December 21, 2020)

renal argyria, arkana laboratories, renal pathology, kidney
What is your diagnosis in a patient with a particular “gray” appearance to their complexion?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​...