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(1357 Results)Extrafusal and Intrafusal Fibers
Clinical History This 1-year-old patient underwent muscle biopsy to evaluate for hypotonia. What are the muscle fibers within the small…
Diagnose This 4/15/2024
Based on the image provided, what would be your leading diagnosis with C3-dominant immune-complex deposition? The light microscopic image depicts…
Signet Ring Carcinoma
Clinical History This 50-year-old patient presented with muscle weakness and stiffness. They had recently been identified to have diffuse thickening…
Oxidative Stain Pallor
Clinical History This 60-year-old patient presented with progressive symmetrical subacute onset proximal muscle weakness involving their lower and upper extremities.…
Diagnose This 4/1/2024
What is this finding and what is the significance in the transplant setting? The light microscopic image depicts an…
Diagnose This 3/18/2024
What is at the top of your differential in a patient with a positive SPEP (IgG kappa) and the immunofluorescence…
Diagnose This 3/11/2024
What is your diagnosis in a patient with nephrotic syndrome? The electron photomicrograph demonstrates frequent subepithelial deposits along the glomerular…
Diagnose This 3/4/2024
The ultrastructural abnormalities present in the image are suspicious for what underlying disease? The electron photomicrograph demonstrates two abnormal…
Denervated Schwann cell
Clinical History This 50-year-old previously healthy patient presented with a several year history of progressive numbness, tingling and distal lower…
Diagnose This 2/26/2024
What is your diagnosis based on the EM image provided? The electron microscopy image provided is that of portions of…
Regenerated Clusters
Clinical History This 60-year-old diabetic patient presented with complaints of bilateral chronic numbness and tingling involving their legs in a…
Diagnose This 2/19/2024
What is your leading diagnosis when seeing this particular IgG staining pattern? Answer: Fibrillary Glomerulopathy The immunofluorescence shows…
Diagnose This 2/12/2024
What is your diagnosis? The light microscopic image depicts a renal transplant biopsy with multiple histiocytes containing intracytoplasmic, targetoid…
Unusual Inflammatory Neuropathy
Clinical History: This 60-year-old patient presented with a history of chronic progressive paresthesias involving all four extremities. Electrodiagnostic studies showed…
Diagnose This 2/5/2024
What is your diagnosis in this transplant biopsy given the features present? Answer: Chronic active antibody-mediated rejection The features…