Clinical History This 60-year-old patient presented with progressive symmetrical subacute onset proximal muscle weakness involving their lower and upper extremities.…

What is this finding and what is the significance in the transplant setting?   The light microscopic image depicts an…

What is at the top of your differential in a patient with a positive SPEP (IgG kappa) and the immunofluorescence…

What is your diagnosis in a patient with nephrotic syndrome? The electron photomicrograph demonstrates frequent subepithelial deposits along the glomerular…

The ultrastructural abnormalities present in the image are suspicious for what underlying disease?   The electron photomicrograph demonstrates two abnormal…

Clinical History This 50-year-old previously healthy patient presented with a several year history of progressive numbness, tingling and distal lower…

What is your diagnosis based on the EM image provided? The electron microscopy image provided is that of portions of…

Clinical History This 60-year-old diabetic patient presented with complaints of bilateral chronic numbness and tingling involving their legs in a…

What is your leading diagnosis when seeing this particular IgG staining pattern?     Answer: Fibrillary Glomerulopathy The immunofluorescence shows…

What is your diagnosis?   The light microscopic image depicts a renal transplant biopsy with multiple histiocytes containing intracytoplasmic, targetoid…

Clinical History: This 60-year-old patient presented with a history of chronic progressive paresthesias involving all four extremities. Electrodiagnostic studies showed…

What is your diagnosis in this transplant biopsy given the features present?   Answer: Chronic active antibody-mediated rejection The features…