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Active vasculitis with fibrinoid necrosis
Neuro Notes

Muscle Pain

Clinical History The patient is a 54-year-old man with lower extremity pain and edema, weakness and fever following a respiratory…

Neuro Notes

Denervated Schwann cell

Clinical History This 50-year-old previously healthy patient presented with a several year history of progressive numbness, tingling and distal lower…

Neuro Notes

Regenerated Clusters

Clinical History This 60-year-old diabetic patient presented with complaints of bilateral chronic numbness and tingling involving their legs in a…


Unusual Inflammatory Neuropathy
Neuro Notes

Unusual Inflammatory Neuropathy

Clinical History: This 60-year-old patient presented with a history of chronic progressive paresthesias involving all four extremities. Electrodiagnostic studies showed…

Degenerative axon/axonal-spheroid
Neuro Notes

Painful Ankle Mass

Clinical History 49-year-old woman Right-sided sural nerve mass Distal pain and numbness of the ankle What is the structure at…

Neuro Notes

27 Weeks Gestation

Clinical History This patient is a newborn male born at 27 wks, 2 days gestation. 25y.o. mother is G1P1 w/…


Neuro Notes

Skull Base Cyst

Clinical History This 35-year-old woman presented with dysphagia and dysphonia. MRI showed a CSF filled, thin-walled cyst compressing medulla. Question…

Neuro Notes

Weakness and Paresthesia

Clinical History: This 52-year-old patient presented with increased weakness and mildly painful paresthesias. Imaging showed hilar adenopathy and a rheumatology…

Peripheral nerve axons
Neuro Notes

Peripheral Nerve Axons

Peripheral Nerve Axons This 60-year-old patient underwent sural nerve biopsy to evaluate for neuropathy. Do the numerous very small punctate…


Small Unmyelinated Fibers Seen In Neurofilament Stain
Neuro Notes

Neurofilament Stain

This 35-year-old patient presented with complaints of numbness and tingling involving their feet, and distal lower extremity muscle weakness. Electrodiagnostic…

Schwann Cell
Neuro Notes

Peripheral Nerve Myelinating Cells

Figure 1 shows a myelin sheath (arrow) with orderly myelin wrapping. No abnormality of myelin periodicity is seen (i.e. no…

By Kelly Mrachek, MD