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congo red stain, lipofuscin, neuro notes, arkana laboratories
Neuro Notes

Other Uses For the Congo Red Stain

Did you know there could be other uses for Congo Red Stain?Additional unintended useful information can be obtained from many…

By Kelly Mrachek, MD
Golgi Tendon Organ
Neuro Notes

Golgi Tendon Organ

In reviewing this skeletal muscle biopsy, what is this structure and what is its function? (Hematoxylin and Eosin stained FFPE…

By Kelly Mrachek, MD
Exocytosis, Neuro Notes, arkana laboratories, muscle biopsy
Neuro Notes

Exocytosis in a Skeletal Muscle Biopsy

This electron micrograph of two adjacent skeletal muscle cells demonstrates simultaneous exocytosis.  Exocytosis in this case shows extravasation of lysosomes…

By Kelly Mrachek, MD

sarcoidosis, neuro notes, arkana laboratories
Neuro Notes

Sarcoidosis in a Skeletal Muscle Biopsy

These images show skeletal muscle from the thigh of an African-American patient with muscle weakness and elevated CPK levels.  Occasional…

By Kelly Mrachek, MD
Lipid Storage Myopathy, Arkana Laboratories, neuro notes, neuropathology, molecular pathology
Neuro Notes

Lipid Storage Myopathy

This adult patient presented with progressive muscle weakness, elevated CK, and was admitted for rhabdomyolysis. Skeletal muscle biopsy was performed…

By Kelly Mrachek, MD
brain biopsy, Diffuse Astrocytoma IDH-Mutant, neuro notes, neuropathology
Neuro Notes

Diffuse Astrocytoma IDH-Mutant

The field of neuropathology is currently in a state of exponential growth and increased understanding of the pathogenesis of brain…

By Kelly Mrachek, MD

pituitary adenoma, pituitary gland tumor, arkana laboratories, neuro notes, neuropathology
Neuro Notes

Pituitary Gland

Using the Wilder’s reticulin special silver stains, can you spot which image shows pathologic change in this endoscopic transnasal transsphenoidal…

Jon Wilson, MD neuropathologist at arkana laboratories
By Jon Wilson, MDKelly Mrachek, MD
Diabetic Polyneuropathy, Hyaline thickening, neuro notes, arkana laboratories, muscle biopsy
Neuro Notes

Diabetic Polyneuropathy

This is an interesting common vascular finding in a sural nerve biopsy taken from an adult diabetic patient with paresthesias. …

Perifascicular Atrophy, neuro notes, Arkana Laboratories, muscle biopsy
Neuro Notes

Perifascicular Atrophy in Dermatomyositis

Perifascicular Atrophy in DermatomyositisThis case shows an acquired inflammatory myopathy with well-developed perifascicular atrophy.  Generally speaking, acquired inflammatory myopathies may…

By Kelly Mrachek, MD

neuro notes, neuropathology, arkana laboratories
Neuro Notes

New Neuropathology Series: Neuro Notes

Introducing Neuro Notes!????   This new series by our neuropathologists, Dr. Wilson and Dr. Mrachek, will be highlighting cases, diagnosing…