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Art of Medicine: Membranous Glomerulopathy
The painting above depicts membranous glomerulopathy. A single glomerular capillary loop with confluent subepithelial and intramembranous electron dense deposits along…
KDIGO Connections: Membranous Glomerulopathy
Welcome to the first post in our new series KDIGO Connections, a series in which we are asking our nephrologist…
Membranous Glomerulopathy in Obesity-Related Glomerulopathy
The patient is a 57-year-old female, with a history of morbid obesity and persistent mild proteinuria (approximately 1 gm), who…
Interstitial Foam Cells
This 52-year-old female underwent a renal biopsy as part of the workup for nephrotic syndrome. The biopsy is diagnostic for…
Diabetic Glomerulosclerosis with Superimposed Diseases
Diabetic glomerulosclerosis is one of the most common causes of nephrotic range proteinuria in adults. When the clinical course of…
Diagnose This (June 25, 2018)
What immunofluorescence stain is shown here, what is the immune complex deposition pattern and what disease does it represent? …
Twitter Poll (June 13, 2018)
ANSWER: CIn patients older than 60 y/o, MGN is associated with malignancy in 20-30% of cases. The lung is most…
Membranous with FSGS
Some patients with membranous glomerulopathy also have associated focal segmental glomerulosclerosis (FSGS) lesions. The glomerulus in this biopsy image, for…
PLA2R Tutorial
The diagnosis of membranous glomerulopathy has been transformed in the past 10 years with the discovery of PLA2R. PLA2R is…
Resolving Membranous Glomerulopathy
A renal biopsy was performed on this 55-year-old female with a history of biopsy-proven membranous glomerulopathy status post immunosuppressive therapy,…
Twitter Poll (February 14, 2018)
ANSWER: B10-15% of cases with renal biopsy findings consistent with PMN (positive PLA2R staining) can have negative PLA2RAb serology at…
Twitter Poll (December 14, 2017)
ANSWER: CPhospholipase A2 receptor 1 (PLA2R1) is present in podocytes and proximal tubules and has been detected in ~70% of…
Diagnose This! (November 27, 2017)
What is your diagnosis (IgG stain shown)? …
Vascular Staining in Membranous
This immunofluorescence (IF) image shows extensive granular glomerular capillary wall IgG deposits, consistent with membranous glomerulopathy. The glomerular staining pattern…