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DNAJB9 helps uncover dual pathology…
This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…
IgA Nephropathy Oxford Scoring
TheIgA nephropathy Oxford Classification was first published in 2009 by a working group of nephrologists and renal pathologists representing the…
IgA Differential
IgA nephropathy is defined by IgA dominant or co-dominant deposits in glomeruli in the absence of systemic disease. Other diseases…
Diagnose This! (January 8, 2018)
The immunofluorescence image shown is of IgA. What is the most likely diagnosis and clinical history? …
IgA with Crescents, MEST-C
This biopsy is from a young adult patient with IgA nephropathy (the immunofluorescence image in Fig. 2 shows 2+ mesangial…
Diagnose This! (October 23, 2017)
This IF image is from a 22 y/o Asian male with hematuria. What immunoreactant does it represent and what is…
Fabry Disease and IgA
A 34-year-old Asian female underwent a renal biopsy as part of the workup for progressively worsening renal function (Cr =…
IgA and APOL1
The presence of two APOL1 risk alleles, which predominantly affect populations of recent African ancestry, confers up to 29x increased…
IgAN and Acute Tubular Injury with Legionella
Acute kidney injury in the setting of Legionella pneumonia. This biopsy is a middle-aged person with Legionella pneumonia who developed…
Renal Medullary Angiitis
This 56-year-old female presented with acute kidney injury, hematuria, and mild proteinuria. All serologic studies were negative except for antineutrophil…
Medullary Angiitis
The attached photomicrographs show the classic histopathology of renal medullary angiitis, a lesion involving the vasa recta of the medulla.…
IgA Nephropathy
Figure 1 shows a renal biopsy from a 29-year-old man with no significant past medical history, who was found to…