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IgA, IgA Differential, IgA nephropathy
Teaching Points

IgA Differential

IgA nephropathy is defined by IgA dominant or co-dominant deposits in glomeruli in the absence of systemic disease. Other diseases…

IgA Nephropathy
Diagnose This!

Diagnose This! (January 8, 2018)

The immunofluorescence image shown is of IgA. What is the most likely diagnosis and clinical history?   …

By L. Nich Cossey, MD
MEST-C, IgA with Crescents
Teaching Points

IgA with Crescents, MEST-C

This biopsy is from a young adult patient with IgA nephropathy (the immunofluorescence image in Fig. 2 shows 2+ mesangial…


IgA nephropathy
Diagnose This!

Diagnose This! (October 23, 2017)

This IF image is from a 22 y/o Asian male with hematuria. What immunoreactant does it represent and what is…

By L. Nich Cossey, MD
Fabry disease
Teaching Points

Fabry Disease and IgA

A 34-year-old Asian female underwent a renal biopsy as part of the workup for progressively worsening renal function (Cr =…

APOL1 risk alleles, IgA and APOL1-Associated Nephropathy
Teaching Points

IgA and APOL1

The presence of two APOL1 risk alleles, which predominantly affects population of recent African ancestry, confers up to 29x increased…


Acute Tubular Injury with Legionella
Teaching Points

IgAN and Acute Tubular Injury with Legionella

Acute kidney injury in the setting of Legionella pneumonia. This biopsy is a middle-aged person with Legionella pneumonia who developed…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
Medullary Angiitis in renal biopsy
Teaching Points

Renal Medullary Angiitis

This 56-year-old female presented with acute kidney injury, hematuria, and mild proteinuria. All serologic studies were negative except for antineutrophil…

Medullary Angiitis
Teaching Points

Medullary Angiitis

The attached photomicrographs show the classic histopathology of renal medullary angiitis, a lesion involving the vasa recta of the medulla.…


IgA Nephropathy
Teaching Points

IgA Nephropathy

Figure 1 shows a renal biopsy from a 29-year-old man with no significant past medical history, who was found to…