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Acute Tubular Injury, globular retractile brightly eosinophilic and fuchsinophilic casts,
Teaching Points

Acute Tubular Injury With Pigmented Casts

This biopsy is a 54-year-old female without significant past medical history, who presented with acute kidney injury. The serum creatinine…

AKI, MCD, renal injury
Teaching Points

Minimal Change Disease and Acute Kidney Injury

This 81-year-old male with past medical history of hypertension and coronary artery disease presents with acute kidney injury (Cr =…

Lead Toxicity, Nephrotoxicity
Teaching Points

Lead Toxicity

The arrow in this image points to a cluster of tubular epithelial cells whose nuclei contain eosinophilic intranuclear inclusions characteristic…


Tenofovir
Teaching Points

Tenofovir

A wide variety of prescription and over the counter drugs may cause toxic injury to the renal tubular epithelium. Given…

Acute Tubular Injury with Legionella
Teaching Points

IgAN and Acute Tubular Injury with Legionella

Acute kidney injury in the setting of Legionella pneumonia. This biopsy is a middle-aged person with Legionella pneumonia who developed…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
(2,8-DHA) 2,8-dihydroxyadenine
Teaching Points

2,8-Dihydroxyadenuria

Adenine phosphoribosyltransferase (APRT) deficiency results from an autosomal recessive enzyme defect of purine metabolism and leads to 2,8-dihydroxyadenine (2,8-DHA) crystalline…


Rhabdomyolysis
Diagnose This!

Diagnose This! (July 24, 2017)

What is your diagnosis?     …

By L. Nich Cossey, MD
Acute Pyelonephritis, arkana laboratories, renal biopsy, renal disease
Teaching Points

Acute Pyelonephritis

The renal biopsy image shows features characteristic of acute pyelonephritis. There is a neutrophil-rich interstitial inflammatory infiltrate and evidence of…

BK virus in renal biopsy at Arkana Laboratories
Teaching Points

BK Nephritis

This biopsy is from a patient with ESRD due to polycystic kidney disease. He is s/p deceased donor renal transplant…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD

warfarin-related nephropathy
Teaching Points

Warfarin

Patients with warfarin-related nephropathy present with an acute rise in serum Cr after becoming supratherapeutic on warfarin therapy (INR>3). The…

Hemoglobin
Teaching Points

Hemoglobin

The H&E photomicrographs show acute tubular injury with eosinophilic beaded casts (arrow). Immunohistochemical stains were strongly positive hemoglobin in the…

Oxalate Nephropathy
Teaching Points

Oxalate Nephropathy

This biopsy is from a patient with metabolic acidosis, a CPK of 8000 mg/dl a creatinine of 22 mg/dl on…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD

Oxalate Nephropathy
Teaching Points

Oxalate Nephropathy

H&E stained section (Fig. 1) demonstrating acute tubular injury with frequent translucent intratubular crystalline deposits on a background of severe…

acute tubular injury with numerous pigmented myoglobin casts
Teaching Points

Myoglobin Casts

A 54-year-old man with a history of hypertension and hypercholesterolemia presented with complaints of generalized muscle stiffness and cola-colored urine.…

calcineurin inhibitor toxicity
Pushing Glass

Pushing Glass (April 18, 2017)

A 45 year-old man received renal transplantation for HCV-associated end stage renal disease. He is currently treated with Sofobuvir, Tacrolimus…

By Dao-Fu Dai, MD