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Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This biopsy was performed on a 58-year-old female who presented with mild proteinuria. The glomeruli show diffuse and global endocapillary…
Thyroidization
One of the many patterns of tubular atrophy in the kidney is the aptly named thyroidization pattern because of its…
Nephronophthisis by Light Microscopy
Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end-stage renal disease in children and…
Smoking-Related Glomerulopathy
A renal biopsy was performed on this 52-year-old male with a history of hypertension and heavy tobacco use, who is…
Nephronophthisis by ISH
Nephronophthisis is an autosomal recessive tubulointerstitial nephropathy that is a leading genetic etiology of end stage renal disease in children…
Diabetic Glomerulosclerosis with Superimposed Diseases
Diabetic glomerulosclerosis is one of the most common causes of nephrotic range proteinuria in adults. When the clinical course of…
Light Chain Deposition Disease
The immunofluorescence in cases of monoclonal immunoglobulin deposition disease is characterized by linear tubular basement membrane staining. In these cases,…
The “C” in CKD
This renal biopsy illustrates severe chronic kidney injury and its effects on all major compartments of the cortex: most glomeruli…
Diagnose This (June 25, 2018)
What immunofluorescence stain is shown here, what is the immune complex deposition pattern and what disease does it represent? …
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This renal biopsy from a 57-year-old male with acute renal failure, hematuria, and nephrotic-range proteinuria shows a proliferative glomerulonephritis (A)…
Immunotactoid Glomerulopathy
Immunotactoid glomerulopathy is one of many glomerular diseases characterized by organized deposits. Figure 1 shows characteristic glomerular changes seen with…
Twitter Poll (June 13, 2018)
ANSWER: C In patients older than 60 y/o, MGN is associated with malignancy in 20-30% of cases. The lung is…
Crescentic Fibrillary Glomerulopathy
Fibrillary glomerulopathy is a rare disorder of unknown etiology and pathophysiology, which is characterized by deposition of course, randomly-oriented, non-branching…
Diagnose This! (June 4, 2018)
The patient is a 67 y/o Caucasian female with slowly progressive kidney disease and 2.3 gm/24 hr proteinuria. Aside from…
IgA Nephropathy Oxford Scoring
TheIgA nephropathy Oxford Classification was first published in 2009 by a working group of nephrologists and renal pathologists representing the…