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IgA and APOL1
The presence of two APOL1 risk alleles, which predominantly affects population of recent African ancestry, confers up to 29x increased…
Diagnose This! (August 14, 2017)
An immunofluorescence panel for IgA, IgG, IgM, C3, C1q, kappa and lambda was negative. What is your diagnosis? …
Randall’s Plaques
Randalls plaques are microscopic calcium phosphate deposits in the basement membranes of the thin loops of Henle. These plaques act…
Pushing Glass (July 25, 2017)
The patient is a 64-year-old female who presents with 4.5 grams of proteinuria, hematuria, and a creatinine of 1.5. She…
Renal Medullary Angiitis
This 56-year-old female presented with acute kidney injury, hematuria, and mild proteinuria. All serologic studies were negative except for antineutrophil…
Thin Basement Membrane Disease
This 41-year-old female presents with microscopy hematuria and subnephrotic proteinuria. The clinical workup is negative for urinary tract infection, nephrolithiasis…
Class III Focal Lupus Nephritis
This 9-year-old female was recently evaluated for lymphoid malignancy due to weight loss and intermittent fevers. Following a negative workup…
Diffuse Mesangial Hypercellularity
This biopsy is from a previously healthy 3 year old female, who presented with sudden onset nephrotic syndrome, hypertension and…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This 76-year-old white female developed nephrotic syndrome over about 3 months. She has proteinuria, 9 gm/24h and an elevated creatinine…
IgA Nephropathy
Figure 1 shows a renal biopsy from a 29-year-old man with no significant past medical history, who was found to…
Pushing Glass (May 2, 2017)
A 45 year-old African American man presented with pneumonia, colitis and acute kidney injury (serum creatinine- 6 mg/dL). What is…
Necrotizing Vasculitis
Necrotizing Vasculitis as seen with Silver Methenamine Massons Trichrome (SMMT) stain on a renal biopsy. The immunofluorescence panel was negative…
Anti-GBM
A 19-year-old Caucasian male patient presented with acute renal failure. Serum creatinine was 4.9 mg/dL and he had hematuria and…
Necrotizing Vasculitis
Necrotizing vasculitis as shown using fluorescence with DAPI-FITC-Texas Red excitation on an H&E stained section. Subtle and not so subtle…
Pushing Glass (March 14, 2017)
The patient is a 61-year-old female who presents with hematuria and a creatinine of 6.23 mg/dL (baseline creatinine of 1.17…