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2,8 DHA Crystalline Nephropathy
Teaching Points

2,8 DHA Crystalline Nephropathy

The renal biopsy shown here has crystals present within the tubular lumens and cytoplasm with a brownish appearance by H&E…

Lithium-Induced Nephropathy, kidney disease, arkana laboratories, acute renal disease
Pushing Glass

Pushing Glass (May 11, 2018)

These images are from the kidney biopsy of a 45-year-old man with a history of hypertension and bipolar disease presenting…

By Md Shahrier Amin, MD
Arteritis
Teaching Points

Chronic Lesions of ANCA – Arteritis

The renal biopsy shown here is from a patient with a remote history of ANCA-associated vasculitis. The artery present in…


AL Amyloidosis
Teaching Points

Vascular-Limited AL Amyloidosis

A renal biopsy was performed on this 78 year old male with history of diabetes mellitus, hypertension and monoclonal gammopathy…

DNAJB9, FGN, biomarker, kidney biopsy
Twitter Poll

Twitter Poll (May 2, 2018)

ANSWER: DNAJB9 DnaJ homolog subfamily B member 9 (DNAJB9) is a novel proteomic tissue biomarker for Fibrillary glomerulonephritis (FGN) that…

By Vanessa Moreno, MD
IgA, IgA Differential, IgA nephropathy
Teaching Points

IgA Differential

IgA nephropathy is defined by IgA dominant or co-dominant deposits in glomeruli in the absence of systemic disease. Other diseases…


LECT2 Amyloidosis, tubulointerstitial and vascular deposition of a PAS-pale
Teaching Points

LECT2 Amyloidosis

The renal biopsy from this 79-year-old Hispanic male shows extensive glomerular, tubulointerstitial and vascular deposition of a PAS-pale (Fig 1),…

Fabry disease
By L. Nich Cossey, MD
fibrosis, Chronic interstitial nephritis, CIN
Teaching Points

CIN Due To PPI

Chronic interstitial nephritis (CIN) is diagnosed when interstitial inflammation is present in areas of fibrosis (A) in combination with the…


Focal segmental glomerulosclerosis (FSGS)
Teaching Points

FSGS Types

The 3 main FSGS Types Are there clues to help distinguish among primary, genetic, and secondary focal segmental glomerulosclerosis (FSGS)…

secondary focal segmental glomerulosclerosis
Diagnose This!

Diagnose This (April 16, 2018)

The immunofluorescence study is negative. What is your diagnosis? …

By L. Nich Cossey, MD
Vascular Resistance
Teaching Points

Vascular Resistance

The sampled artery in this kidney biopsy shows severe arteriosclerosis. The deleterious effects of a narrowed arterial lumen and increased…


Sickle Cell Nephropathy
Twitter Poll

Twitter Poll (March 28, 2018)

ANSWER: D Some of the histologic features observed in Sickle Cell Nephropathy that involve the glomerular compartment are: enlarged glomeruli…

By Vanessa Moreno, MD
jones stain, masked IgG kappa deposits
Teaching Points

Membranous-Like Glomerulopathy with Masked IgG-Kappa Deposits

Immunoglobulin deposits identified on renal biopsy samples by paraffin immunofluorescence that show negative staining by routine immunofluorescence on frozen tissue…

A-galactosidase A , pushing glass, arkana laboratories, kidney disease
Pushing Glass

Pushing Glass (March 23, 2018)

These images are from the kidney biopsy of a 70-year-old woman with a history of hypertension and valvular heart disease…

By Md Shahrier Amin, MD