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Twitter Poll (January 16, 2019)
ANSWER: B The target of the circulating ABBA autoantibodies is LDL receptor-related protein 2 (LRP2) also known as Megalin. ABBA…
KDIGO Connections: Membranous Glomerulopathy
Welcome to the first post in our new series KDIGO Connections, a series in which we are asking our nephrologist…
Disease Week: Fibrillary Glomerulopathy
Monday Did you know Fibrillary Glomerulopathy was described in the 1980s? While case reports existed before, in 1983 a series…
Step By Step
The biopsy is from a 65 year-old female who presented with acute renal failure and elevated creatinine up to 1.9…
Twitter Poll (November 15, 2018)
ANSWER: A The number of nephrons in the normal kidney is important because they may play a role in the…
Diagnose This (November 12, 2018)
What is your diagnosis and what do you need to prove it? …
IgA nephropathy with something extra…
The biopsy is from a 61-year-old man with a history of intermittent microscopic hematuria for many years who presents with…
DNAJB9 helps uncover dual pathology…
This case illustrates the utility of immunohistochemical staining for DNAJB9, a recently described biomarker for fibrillary glomerulopathy (see reference). The…
Not Quite Nodular
This biopsy came from a 70-year-old gentleman with acute renal failure. He had a known history of diabetes, hypertension, and…
Membranous Glomerulopathy in Obesity-Related Glomerulopathy
The patient is a 57-year-old female, with a history of morbid obesity and persistent mild proteinuria (approximately 1 gm), who…
Twitter Post (August 30, 2018)
ANSWER: B Type II (mixed) cryoglobulinemia is characterized by immune-complexes containing a monoclonal Ig (usually IgM) that have an RF…
Differential Diagnosis of Kidney Injury in CLL/SLL Patients
There are many causes of decreased kidney function in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and a renal…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This biopsy was performed on a 58-year-old female who presented with mild proteinuria. The glomeruli show diffuse and global endocapillary…
One little, two little, three little findings…
This biopsy came to us for evaluation of nephrotic syndrome. The patient is a Hispanic gentleman in his late 80s,…
Anti-VEGF Effect
This biopsy was taken from an older adult man with acute kidney injury and non-nephrotic range proteinuria. His medical history…