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Obsolescent Pattern in Glomerulosclerosis
Teaching Points

Global Glomerulosclerosis: Obsolescent Pattern

The image shows two globally sclerotic glomeruli exhibiting the so-called obsolescent pattern of glomerular sclerosis. The two key histologic features…

Fabry Disease
Teaching Points

Fabrys

This biopsy shows glomeruli with visceral epithelial cells (podocytes) displaying ample vacuolated cytoplasm (Fig 1), which is highlighted on a…

(CIN) Chronic Interstitial Nephritis
Teaching Points

Chronic Interstitial Nephritis

Chronic interstitial nephritis is a diagnosis made on renal biopsy when interstitial inflammation is present in a background of fibrosis…


FSGS Tip Lesion
Teaching Points

FSGS Tip Lesion – Secondary

The patient is a 64-year-old male with a history of diabetes mellitus, hypertension, and hyperlipidemia, who presents with an increased…

Karyomegalic Nephropathy
Teaching Points

Karyomegalic Nephropathy

This kidney biopsy from a 41-year-old male with CKD is remarkable for the enlarged and pleomorphic tubular nuclei with focal…

Uric Acid Nephropathy
Pushing Glass

Pushing Glass (June 13, 2017)

A 69-year-old African American woman had a kidney biopsy due to CKD III-IV. Her medical history is significant for morbid…

By Md Shahrier Amin, MD

Eosinophil-Rich Inflammation in Diabetic Glomerulopathy
Teaching Points

Eosinophil-Rich Inflammation in Diabetic Glomerulopathy

These photomicrographs are from a patient with diabetic nephropathy as evidenced by the Kimmelstiel-Wilson nodules in the glomerulus present on…

Fabry EM
Teaching Points

Fabry EM

Electron photomicrograph of a glomerular podocyte showing the characteristic electron dense laminated inclusions of Fabry disease. Fabry is a lysosomal…

IgG4-Positive Plasma Cells
Teaching Points

IgG4

Renal parenchyma with florid interstitial fibrosis with thick bands of sclerosis expanding the interstitium and pushing the tubules apart on…


Proliferative Glomerulonephritis with Monoclonal IgG Deposits (PGMID)
Teaching Points

Proliferative Glomerulonephritis with Monoclonal IgG Deposits

This 76-year-old white female developed nephrotic syndrome over about 3 months. She has proteinuria, 9 gm/24h and an elevated creatinine…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
Teaching Points

Proliferative Glomerulonephritis with Monoclonal IgG Deposits

The glomerulus pictured for light microscopy shows membranoproliferative changes with mesangial hypercellularity, GBM duplication, and endocapillary proliferation. There is light…

Lipoprotein Glomerulopathy
Diagnose This!

Diagnose This! (April 24, 2017)

What is the finding shown and what disease does this likely represent?   …

By L. Nich Cossey, MD

Diffuse and Nodular Glomerulosclerosis in Diabetic Glomerulopathy
Teaching Points

Diffuse and Nodular Glomerulosclerosis in Diabetic Glomerulopathy

Diffuse and nodular glomerulosclerosis is the classic appearance of diabetic glomerulopathy. Note the variability in mesangial areas in this one…

Patrick D. Walker, MD renal pathologist at arkana laboratories
By Patrick D. Walker, MD
Arteriosclerosis
Teaching Points

Arteriosclerosis

A very common vascular histologic finding in patients with hypertensive nephrosclerosis is arteriosclerosis. In advanced lesions, such as this example,…

Collagenofibrotic Glomerulopathy
Diagnose This!

Diagnose This! (February 20, 2017)

The patient is a 42 y/o Southern Indian male who presents with longstanding, subnephrotic proteinuria, mild edema, and renal insufficiency.…

By L. Nich Cossey, MD