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Global Glomerulosclerosis: Obsolescent Pattern
The image shows two globally sclerotic glomeruli exhibiting the so-called obsolescent pattern of glomerular sclerosis. The two key histologic features…
Fabrys
This biopsy shows glomeruli with visceral epithelial cells (podocytes) displaying ample vacuolated cytoplasm (Fig 1), which is highlighted on a…
Chronic Interstitial Nephritis
Chronic interstitial nephritis is a diagnosis made on renal biopsy when interstitial inflammation is present in a background of fibrosis…
FSGS Tip Lesion – Secondary
The patient is a 64-year-old male with a history of diabetes mellitus, hypertension, and hyperlipidemia, who presents with an increased…
Karyomegalic Nephropathy
This kidney biopsy from a 41-year-old male with CKD is remarkable for the enlarged and pleomorphic tubular nuclei with focal…
Pushing Glass (June 13, 2017)
A 69-year-old African American woman had a kidney biopsy due to CKD III-IV. Her medical history is significant for morbid…
Eosinophil-Rich Inflammation in Diabetic Glomerulopathy
These photomicrographs are from a patient with diabetic nephropathy as evidenced by the Kimmelstiel-Wilson nodules in the glomerulus present on…
Fabry EM
Electron photomicrograph of a glomerular podocyte showing the characteristic electron dense laminated inclusions of Fabry disease. Fabry is a lysosomal…
IgG4
Renal parenchyma with florid interstitial fibrosis with thick bands of sclerosis expanding the interstitium and pushing the tubules apart on…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
This 76-year-old white female developed nephrotic syndrome over about 3 months. She has proteinuria, 9 gm/24h and an elevated creatinine…
Proliferative Glomerulonephritis with Monoclonal IgG Deposits
The glomerulus pictured for light microscopy shows membranoproliferative changes with mesangial hypercellularity, GBM duplication, and endocapillary proliferation. There is light…
Diagnose This! (April 24, 2017)
What is the finding shown and what disease does this likely represent? …
Diffuse and Nodular Glomerulosclerosis in Diabetic Glomerulopathy
Diffuse and nodular glomerulosclerosis is the classic appearance of diabetic glomerulopathy. Note the variability in mesangial areas in this one…
Arteriosclerosis
A very common vascular histologic finding in patients with hypertensive nephrosclerosis is arteriosclerosis. In advanced lesions, such as this example,…
Diagnose This! (February 20, 2017)
The patient is a 42 y/o Southern Indian male who presents with longstanding, subnephrotic proteinuria, mild edema, and renal insufficiency.…