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Gonadotroph Adenoma
Neuro Notes

Gonadotroph Adenoma

The patient is an obese middle-aged male who presents with complaints of headaches, vision changes, and loss of libido. Neuroimaging…

By Kelly Mrachek, MD
Cerebral Amyloid Angiopathy, Neuro Notes, Neuropathology
Neuro Notes

Cerebral Amyloid Angiopathy

The patient is a male in his 7th decade who presents with left occipital hemorrhagic stroke. The patient has a…

By Kelly Mrachek, MD
Myotonic Dystrophy Type 2
Neuro Notes

Myotonic Dystrophy Type 2

A 55-year-old male with Myotonic Dystrophy Type 2 (DM2). Frozen sections of skeletal muscle stained with H&E show moderate to…

By Kelly Mrachek, MD

Anti-SRP Myopathy in neuro muscle biopsy
Neuro Notes

Anti-SRP Myopathy with Chronicity

The patient is an 80-year-old female who presents with chief complaint of progressive proximal muscle weakness and carries a clinical…

By Kelly Mrachek, MD
STIM1 and ORAI1
Neuro Notes

STIM1 and ORAI1

Considering the clinical vignette from the prior week (elderly male with proximal muscle weakness). Staining the skeletal muscle biopsy with…

By Kelly Mrachek, MD
Tubular aggregates in H&E stain of muscle/nerve biopsy
Neuro Notes

Tubular Aggregates

Considering the clinical vignette from the prior week (elderly male with proximal muscle weakness). Staining the skeletal muscle biopsy with…

By Kelly Mrachek, MD

Modified Gomori Trichrome (MGT)
Neuro Notes

Modified Gomori Trichrome (MGT)

What does modified gomori trichrome (MGT) show? Considering the clinical vignette from the prior week (elderly male with proximal muscle…

By Kelly Mrachek, MD
Myopathy with Tubular Aggregates
Neuro Notes

Myopathy with Tubular Aggregates

Considering the clinical vignette from last week (elderly male with proximal muscle weakness). Staining the skeletal muscle biopsy with myoadenylate…

By Kelly Mrachek, MD
Neuro Notes

Tubular Aggregate Myopathy

A 75-year-old male presents with progressive generalized muscle weakness, issues with balance, back pain, as well as numbness and tingling…

By Kelly Mrachek, MD

Fibrous Body, neuro path, arkana laboratories, Muscle biopsy
Neuro Notes

Fibrous Body

A 75-year-old female patient presents with proximal muscle weakness, characteristic skin rash, and dysphagia. Laboratory workup reveals elevated CPK 3500.…

By Kelly Mrachek, MD
congophilic inclusions, sporadic Inclusion Body Myositis, neuropathology, arkana laboratories, neuro notes
Neuro Notes

Congophilic Inclusions

A 68-year-old man presents with insidiously progressive proximal left thigh weakness with atrophy, left foot drop, and right hand grip…

By Kelly Mrachek, MD
Renaut body, neuro notes, muscle biopsy, neuropathology
Neuro Notes

Renaut Body

Figure 1: Cross section of sural nerve with Renaut Body (arrow) and background moderate diffuse axonopathic process. Plastic embedded thick…

By Kelly Mrachek, MD

Denervation MCQ, Denervation type changes, neuropathology, neuro notes, arkana laboratories
Neuro Notes

Denervation MCQ

Frozen section of skeletal muscle stained with nonspecific esterase. (Original magnification: 100x) A 45-year old male firefighter with diabetes mellitus…

By Kelly Mrachek, MD
Satellite Cells, Neuro Notes, neuropathology, arkana laboratories
Neuro Notes

Satellite Cells

An adult patient with proximal muscle weakness presents with CK 4400 and skeletal muscle biopsy of the thigh shows frequent…

By Kelly Mrachek, MD
Nemaline Rods, neuro notes, neuropathology, Dr. Mrachek
Neuro Notes

Nemaline Rods

What are these dark (osmophilic) structures seen in this electron micrograph of skeletal muscle?   These osmophilic structures are Nemaline…

By Kelly Mrachek, MD