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January 11, 2022

Diagnose This (January 10, 2022)

This is the H&E from the frozen tissue submitted for IF examined under fluorescent light. In a patient with anemia, thrombocytopenia, high LDH and schistocytes, what is your diagnosis?   

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The image shows a fibrin thrombus located at the hilum of the glomerulus. This finding is consistent with thrombotic microangiopathy. Light microscopy demonstrated numerous glomerular and arteriolar fibrin thrombi (Figure 2). By electron microscopy, subendothelial lucent widening and new glomerular basement membrane formation were present (stars, Figure 3).