November 30, 2021
Diagnose This (November 29, 2021)
What is your differential diagnosis for this ultrastructural finding?
The EM picture shows subendothelial lucent widening and new glomerular basement membrane formation, in the absence of immune-type electron-dense deposits. This finding is indicative of chronic endothelial injury and can be seen in the setting of chronic thrombotic microangiopathy, antibody-mediated rejection, sickle cell nephropathy, among others.