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October 13, 2021

Viral-like Inclusions in COVID-19 Negative Renal Biopsies by Electron Microscopy

Hosts:

In Episode 4 of Arkana Advances, Dr. May interviews Dr. Cassol over her recent publication discussing viral-like inclusions in COVID-19 negative renal biopsies detected by electron microscopy.

 

Early in the COVID-19 pandemic in the United States, few publications from different organ systems claimed to have found COVID-19 viral particles, including in the kidney. Viral particles are known to be of varying sizes, making proper identification even more difficult. To see whether these viral particles are specific for COVID-19 infection, both pre-COVID and COVID-era biopsies were examined. Viral-like inclusions were seen in all cases studied. These mimickers of COVID virions are hypothesized to be clathrin-coated endocytic vesicles, microvesicular bodies, or small organelles. COVID-19 ISH was performed in a few cases of patients with active COVID, and no viral RNA was detected. The CDC has outlined principles of identification of viruses on electron microscopy, including the proper protocols for preparation of the samples.

 

Read the Paper: Viral-like Inclusions in COVID-19 Negative Renal Biopsies by Electron Microscopy

Watch the Episode: https://youtu.be/45-ZHL1gVSc