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Primary FSGS-Complexa, Inc.


A Phase 2 Multicenter, Open Label, Randomized Study of Two Titration Regimens of Oral CXA-10 in Subjects with Primary Focal Segmental Glomerulosclerosis

Listed below are a few highlights of the inclusion and exclusion criteria for the study.  For a more detailed list of these criteria please click on the clinical trial link below.

Inclusion Criteria

  • Primary FSGS diagnosis by renal biopsy; all histologic types are acceptable except collapsing variant
  • Male or female over 18 years of age
  • eGFR > 45/mL/min/1.73m2
  • Up/c ratio > 2g protein/g creatinine at time of screening and a history of Up/c ratio > 3g protein/g creatinine at some point since disease onset
  • Must be on an ACEi and/or ARB regimen for a minimum of 4 weeks prior to screening

Exclusion Criteria

  • Subject has collapsing variant of FSGS on renal biopsy
  • Subject has diabetic nephropathy
  • Subject has a history of any primary malignancy
  • Subject has a history of organ transplantation
  • Subject has a history of HIV
  • Subject has received systemic high-dose, long-term corticosteroid therapy to treat kidney disease

For more information or if you have questions about this trial, please click on the link:  http://firstx-trial.com/