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Currently filtering by tag: Acute interstitial nephritis

Twitter Poll (November 1, 2018)

Drug-induced AIN, Twitter Poll, Arkana Laboratories
ANSWER: D Drug-induced AIN may account for 60-70% of AIN cases. Some offending drugs include: antibiotics, proton pump inhibitors, NSAIDs, PD1-inhibitors, anti-convulsants, and diuretics, among others. References: Cortazar FB et al. Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors. Kidney Int 2016; 90: 638-47 Muriithi AK et al. Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly. Kidney Int 2015; 87: 458-464. Muriithi AK et al. Biopsy-proven acute interstitial nephritis. Nat Rev Nephrol 2010; 6(8): 461-70 Praga M et al. Acute interstitial nephritis. Kidney Int 2010; 77(11): 956-61

Polyomavirus Nephropathy in Native Kidney

Polyomavirus Nephropathy in Native Kidney
Polyomavirus nephropathy (PVN), predominantly caused by BK virus reactivation in the urogenital tract, is an important complication of renal allografts (reference 1). While it rarely affects the native kidney, it may be seen in the setting of chronic immunosuppression, including bone marrow transplantation, HIV infection, chemotherapy and in the setting of other solid organ transplants (reference 2). The case shown is from a 69-year-old female with a history of sarcoidosis and cirrhosis who is now 5 years post liver transplant. The patient is currently being evaluated for a progressive increase in serum creatinine. The biopsy shows significant, non-specific tubulointerstitial scarring...

Adenovirus

Adenovirus, interstitial hemorrhage and edema
This allograft biopsy shows the characteristic features of adenovirus infection. There is prominent interstitial hemorrhage and edema (Fig. 1), acute tubular injury with viral cytopathic effect and positive immunohistochemical cytoplasmic and nuclear staining for adenoviral antigen (Fig. 2), and foci of tubular necrosis (Fig. 3). The differential diagnosis for this morphology in the transplant setting includes other viral infection (e.g. polyomavirus, CMV, HSV), acute rejection, and drug-related acute interstitial nephritis.

Diagnose This! (May 14, 2018)

Acute Interstitial Nephritis
What is your diagnosis?    ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​...