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Diabetic Nephropathy

Protein Insudative Lesions in Diabetic Glomerulopathy Diffuse and nodular glomerulosclerosis is the classic appearance of diabetic glomerulopathy. However, diabetic nephropathy also includes so-called insudative lesions including “Fibrin Caps” and “Capsular Drops”. These lesions are characteristically seen in diabetics with nephrotic range proteinuria and are thought to be the result of ‘insudation’ of protein and other serum products into the space between the cell lining and its supporting basement membrane. In the case of the Fibrin Cap, the lesion is seen between the endothelium and the glomerular basement membrane (Blue Arrows, Jones Silver 400x). Fibrin cap is a misnomer because there...