arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal

Blog


Currently filtering by tag: Fibrinogen A-alpha amyloidosis

Fibrinogen Aα-chain Amyloidosis

A 65-year-old male, with no significant past medical history, presents with proteinuria and worsening renal function. The serum creatinine is 2.4 mg/dl and the UPCR is 2.5 g/g.  Serum and urine protein electrophoresis with immunofixation shows the absence of monoclonal immunoglobulin.  Free serum light chain ratio is within normal limits.  Remaining of serologies are also negative/normal.  A renal biopsy was performed and representative images are shown (Fig 1-5).  The glomeruli are markedly enlarged and show massive deposition of PAS-pale (Fig 1), weakly argyrophilic (Fig 2), Congo red positive (Fig 3) amorphous material which shows apple green birefringence upon polarization (Fig...