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Currently filtering by tag: Hemosiderosis


renal hemosiderosis, arkana laboratories, teaching point, renal pathology
An 80-year-old white male presents with a creatinine of 4.2 (baseline 1.1) on routine lab examination. His medical history is significant for coronary artery disease, aortic valve replacement, hypertension, and peripheral artery disease. He reports no episodes of dehydration and reports that he has been in his normal state of health. Figure 1 shows a normal glomerulus. Figure 2 shows a mild interstitial fibrosis. Figure 3 shows brown spherules within the tubular epithelial cells. Figure 4 confirms the presence of iron within these brown spherules. This is a case of renal hemosiderosis. The presence of iron deposits speaks towards intravascular...


Renal hemosiderosis is a rare etiology of kidney injury that occurs secondary to diseases with chronic intravascular hemolysis. The most common associated conditions include paroxysmal nocturnal hemoglobinuria, sickle cell anemia, and the presence of a mechanical heart valve. It results from free hemoglobin being filtered by the glomeruli and reabsorbed by the proximal tubules. H&E and PAS sections show proximal tubules with cytoplasmic golden yellow to brown, granular pigment. These granules stain blue on a Prussian blue iron stain.