- Published: August 28, 2018
- By: Alejandro Best, MD
- Tags: Chronic kidney disease, Membranoproliferative pattern glomerulonephritis, Proliferative glomerulonephritis with IgG deposits, Proteinuria
This biopsy was performed on a 58-year-old female who presented with mild proteinuria. The glomeruli show diffuse and global endocapillary hypercellularity with segmental double contour formation of the capillary loops on the silver stain (Fig 1). Immunofluorescence shows mesangial and segmental capillary wall deposits positive for IgG (3+, Fig 2), C3 (3+, not shown), C1q (1+, not shown) and lambda light chain (3+, Figure 4). Staining for kappa light chain is negative in glomeruli (Fig 3). Further immunofluorescence staining for IgG subclasses proves the deposits to be IgG3 restricted. Electron microscopy shows mesangial and segmental subendothelial immune-complex type deposits. The...