arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal

Blog


Currently filtering by tag: Membranous lupus nephritis

Diagnose This! (November 27, 2017)

What is your diagnosis (IgG stain shown)?     ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​  ...

Vascular Staining in Membranous

This immunofluorescence (IF) image shows extensive granular glomerular capillary wall IgG deposits, consistent with membranous glomerulopathy. The glomerular staining pattern as seen by IF is not specific for either primary or secondary membranous glomerulopathy. However, the prominent IgG deposits also involving the associated arteriole in this case are an important clue that helps argue for a secondary etiology. This patient, in fact, was found to have systemic lupus erythematosus.

Subepithelial Deposits in Lupus Nephritis

According to the ISN/RPS 2003 classification of lupus nephritis, membranous lupus nephritis (class V) is characterized by the presence of global or segmental subepithelial immune deposits with or without associated mesangial deposits or mesangial hypercellularity. Membranous lupus nephritis may occur in isolation or may coexist with other forms of active lupus nephritis such as focal (class III) or diffuse (class IV) lupus nephritis. In the presence of active glomerular lesions, scattered subepithelial deposits are common and are not diagnostic of membranous lupus nephritis (class V). In fact, in order to make a diagnosis of membranous lupus nephritis (class V) in...

Diagnose This! (June 26, 2017)

What’s your diagnosis?     ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​...