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The above painting shows normal bone marrow, containing erythroid and myeloid precursors at various stages of maturation and normal trabeculae. Bone marrow biopsies may be performed to evaluate for a lymphoid or plasma cell clone in patients with monoclonal gammopathies of undetermined significance and in work-up of patients found to have a monoclonal gammopathy of renal significance (MRGS). Monoclonal gammopathies of renal significance occur when light chain restriction within a kidney biopsy is thought to be responsible for the patient's renal dysfunction, which is usually acute kidney injury or proteinuria. This includes a broad spectrum of findings, which includes but...