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Currently filtering by tag: Myoglobin cast nephropathy

Diagnose This (November 19, 2018)

What is your diagnosis? What additional stains would you like to confirm your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​...

Diagnose This (May 21, 2018)

What is your diagnosis?   ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​...

ATI With Pigmented Casts

This biopsy is a 54-year-old female without significant past medical history, who presented with acute kidney injury. The serum creatinine at presentation was 7.2 mg/dl. Light microscopy shows diffuse acute tubular injury characterized by marked attenuation of the tubular epithelium with loss of the proximal tubular brush borders (not shown). Additionally, the tubular lumens frequently show globular, retractile, brightly eosinophilic and fuchsinophilic casts, without an associated cellular reaction (Fig 1, PAS; Fig 2, Trichrome). The differential diagnosis of acute tubular injury with pigmented casts includes hemoglobin cast nephropathy, myoglobin cast nephropathy, bile cast nephropathy, light chain cast nephropathy and acute...

Diagnose This! (July 24, 2017)

What is your diagnosis?       ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​  ...