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Currently filtering by tag: Normal glomerulus

Malpighi Glomerulus

How long have we known about glomeruli? Today’s teaching point is offered in honor of Marcello Malpighi (1628-1694), the Italian anatomist who is credited with having published the world’s first accurate description of glomerular structure (Bologna, Italy 1666). We learn from those who teach us! Bellomo G. A short history of 'glomerulus'. Clin Kidney J. 2013 Apr;6(2):250-1. PMID: 26019863 Fogazzi GB. The description of the renal glomeruli by Marcello Malpighi. Nephrol Dial Transplant. 1997 Oct;12(10):2191-2. PMID: 9351094. Image Credit (for oil painting, Malpighi): Wellcome Collection (https://wellcomecollection.org/) Podcast on Malpighi: https://www.arkanalabs.com/podcasts/malpighi/ 

Diagnose This! (September 25, 2017)

What is your diagnosis?     ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​...

Normal Histology

This is a normal glomerulus by light microscopy using the Jones silver stain. This section is fortuitously cut through the central plane of the spherical glomerulus. Note the proximal tubule arising at the top of the glomerulus, the so-called ‘tip area’ (green arrows). The hilum at the bottom of the photo contains the vascular entry and exit points as well as the juxtaglomerular apparatus (blue arrowhead). The glomerular basement membranes are delicate and without interruption. No endocapillary proliferation is present. The centrally located mesangial regions are not expanded and there is no mesangial hypercellularity. (Jones Silver 400x)