arrow-right-realarrow-right-whitearrow-rightback-to-topdoctordownloadfacebookinstagramlogo-markerlogo-wordmarkpodcastsearchsearch_whitetwitter
Close Modal

Blog


Currently filtering by tag: Transplant Glomerulopathy

Twitter Poll (February 12th)

Transplant glomerulopathy, twitter poll,
Answer: C Transplant glomerulopathy (TG) is characterized by duplication of glomerular basement membrane (GBM) and is graded based on the percentage of glomerular capillary loops with GBM duplication or double contours in the most affected non-sclerotic glomerulus by LM. Transplant glomerulopathy often indicates the presence of chronic antibody mediated rejection, for which there will be glomerulitis (B), C4d positivity in PTCs (C), and mesangial matrix increase (A).  These findings are not in isolation from one another, therefore, "all of the above" would also be a correct answer. The Banff Lesion Score cg is based on the presence and extent of...

Diagnose This! (February 19, 2018)

What is your diagnosis in this renal transplant patient?     ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​    ...

Antibody-Mediated Rejection

This biopsy was performed on a 37-year-old female with a history of type 1 diabetes mellitus, status post second deceased donor renal transplant, who now presents with allograft dysfunction (Cr 3.1 mg/dl) and mild proteinuria (UPC 1.1 g/g). No donor-specific antibody (DSA) data was available at the time of the biopsy. The biopsy shows severe glomerulitis and chronic transplant glomerulopathy (Fig 1), along with mild peritubular capillaritis (Fig 2) and diffusely positive C4d staining in peritubular capillaries (Fig 3). Based on the Banff 2017 kidney meeting report, this case can now be diagnosed as chronic active antibody-mediated rejection, and the...