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Currently filtering by tag: Uric acid nephropathy

Chronic Uric Acid Nephropathy

Chronic uric acid nephropathy results from deposition within the renal parenchyma of monosodium urate monohydrate. While the disease may occur in the setting of increased uric acid production, it is overwhelmingly more common in the setting of decreased uric acid excretion. Histologically, chronic uric acid nephropathy is characterized by the presence of tubulointerstitial microtophi within the renal medulla, associated with interstitial fibrosis and inflammation. Microtophi are deposits of monosodium urate crystals surrounded by giant cells, epithelioid histiocytes and lymphocytes, which may have a radial needle-like cleft (Fig 1 – blue arrow; Fig 2) or amorphous morphology (Fig 1 – orange...

Pushing Glass (June 13, 2017)

A 69-year-old African American woman had a kidney biopsy due to CKD III-IV. Her medical history is significant for morbid obesity, diabetes mellitus (>5 years), hypertension (>5 years), coronary artery disease status post stent, hypothyroidism, gout and chronic kidney disease. Her renal ultrasound shows an unremarkable simple left renal cyst and increased echogenicity in both kidneys. Investigations show serum creatinine which has increased to 4.9 mg/dl. Proteinuria is up to 3.7 gm/day. Serological studies are negative. The images are characteristic findings of which of the following: 1. Sarcoidosis 2. Acute Tubular Injury 3. Uric Acid Nephropathy 4. Interstitial Nephritis 5....