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Art of Medicine: Uromodulin

Welcome to our first post in the Art of Medicine series! In the hustle and bustle of busy clinics, labs, and hospitals we are often focused on the practical aspects of the practice of medicine. Dr. Tiffany Caza is the content creator for this series as well as being a renal pathologist and artist. Her art focuses on her interpretations of the histologic, cellular, and sub-cellular milieu where a dazzling variety of chemical and structural forces inherent to all life exist. In this series, she will be sharing her art (and occasionally others) and providing correlates to the science represented...

Twitter Poll (September 6, 2018)

ANSWER: A - Thick ascending limb of the loops of the Henle THP (aka uromodulin) is an 85 -kDa glycoprotein encoded by the UMOD gene in humans.  It’s involved in the pathogenesis of light chain cast nephropathy, urolithiasis, and tubulointerstitial nephritis, in urothelial cytoprotection against UTIs, and in mutations of the THP gene in FJHN and MCKD2. References: Micanovic R, et al. Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis. J Am Soc Nephrol 2015; 26(9): 2172-2182. Serafini-Cessi F, et al. Tamm-Horsfall glycoprotein: biology and clinical relevance. Am J Kidney Dis 2003; 42: 658-676. Nasr SH, et al. Uromodulin storage...