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Currently filtering by tag: Vascular disease

Cholesterol Microemboli

Cholesterol emboli involving the kidney may manifest clinically as acute kidney injury, hematuria, proteinuria (both non-nephrotic and nephrotic range), and even new-onset hypertension. This biopsy illustrates a rare example of glomerular involvement (Fig. 1). Most emboli are identified “upstream” within interlobular and/or arcuate arteries (Fig. 2). Prior to this biopsy, the patient had recently undergone an arterial catheterization procedure. Lusco MA, et al. AJKD Atlas of Renal Pathology: Cholesterol Emboli. Am J Kidney Dis. 2016 Apr; 67(4):e23-4. PMID: 27012950.

Cryoglobulinemic Intimal Arteritis

This photomicrograph shows an artery with intimal edema and inflammation in a renal biopsy from a 56-year-old male with renal failure and nephrotic-range proteinuria. The patient’s serologic workup revealed evidence of an HCV infection and a positive rheumatoid factor. While the intima is inflamed and edematous, the media is relatively intact without inflammation or necrosis. Intimal arteritis is a pattern of vascular inflammation most commonly encountered in the transplant setting where it represents a rejection process. In the native kidney, this finding is most commonly seen in cryoglobulinemic vasculitis (which was the case for this patient). The differential diagnosis would...