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Archive: November 2019

Disease Week: Zebrafish Model Organism

Zebrafish first emerged over three decades ago as a promising animal model to better understand embryonic development in vertebrates. Recently, it has gained a foothold as a model to study human diseases and for drug discovery. Despite the vast amount of evolutionary time separating fish from humans, we share important similarities including most of our major organ systems as well as 70% of our genes. As such, many diseases can be modeled and studied in zebrafish. Unlike mammals, adult zebrafish have a nearly unparalleled regenerative capacity to replace and repair injured tissues including heart, spinal cord, and brain. Understanding how...

Membranous Glomerulopathy Subtyping

The diagnosis of membranous glomerulopathy has evolved rapidly in the past 10 years since the identification of PLA2R as the major target antigen in primary membranous glomerulopathy. Today, rather than subtyping into vague categories such as 'primary' and 'secondary', we have tools available to name the specific type of disease present in most cases. Arkana Laboratories offers diagnostic testing for membranous glomerulopathy including immunohistochemical stains for tissue typing of PLA2R, THSD7A, EXT1/2, and NELL1 membranous and serum testing to monitor disease in patients with PLA2R and THSD7A-associated membranous glomerulopathy.