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Vasculitis: Using Fluorescence Microscopy to Visualize Elastic Lamina
Clinical History:This 65-year-old patient presented with a two-month history of progressive proximal upper and lower extremity muscle weakness, and photosensitive…
Glom Goals: A Blueprint for Better Renal Biopsies
In this episode of Glom Goals, we spoke to Dr. Salil Parikh from the Methodist Le Bonheur Healthcare group in…
Glom Goals: Why Adequacy Matters
Renal pathologists Dr. Shree Sharma and Dr. Tiff Caza sit down with nephrologists Dr. Juan Carlos Velez, Dr. Bill Whittier,…
Collagen Pockets in Nerve Biopsy
Clinical History:This 40-year-old patient underwent sural nerve biopsy to evaluate for a painful mixed large fiber and small fiber axonal…
Denervated Neuromuscular Junctions
Clinical History:Muscle biopsy from this 40-year-old patient showed morphologic and enzyme histochemical features of denervation.What abnormality is seen in the…
Gallyas Stain: Plaques, Tangles, and Threads in Alzheimer’s Disease
Clinical History:Neuropathologic examination (brain autopsy) on this 65-year-old patient with a history of slowly progressive dementia demonstrated gross and microscopic…
Myopathic changes on Alkaline phosphatase
Clinical History:This 40-year-old patient presented with complaints of muscle weakness and myalgias of approximately 3-months duration. Laboratory studies showed elevated…
Ring Fibers
Which genetic test is required to establish the diagnosis in this 59-year-old with distal muscle weakness, mild myotonia, and persistently…
Vacuolar myopathy in 92-year-old male
Clinical History:The patient is a 92-year-old-male and presented progressive muscle weakness that began in the left upper extremity and spread…
76-year-old with numbness
Clinical History:The patient has numerous complaints including weakness, myalgia, arthralgia, back pain radiating down bilateral legs, cramps and twitching, imbalance,…
Perineurial microcalcification
Clinical History:This 55-year-old patient presented with symmetrical numbness, tingling and burning sensation involving the bottom of their feet which slowly…
Glom Goals: Why Adequacy Matters
Renal pathologists Dr. Shree Sharma and Dr. Tiff Caza sit down with nephrologists Dr. Juan Carlos Velez, Dr. Bill Whittier,…
Hybrid myofibers
Clinical History: This previously healthy 35-year-old patient presented with proximal upper and lower extremity weakness and myalgias. Laboratory studies showed…
End-stage nerve
Clinical History:This 45-year-old patient underwent sural nerve biopsy to evaluate for potential etiologies of their progressive sensorimotor predominantly axonal polyneuropathy.…
Freezing artifact formalin-fixed tissue
Clinical History: This 50-year-old patient presented with generalized muscle weakness and elevated CPK levels. Muscle biopsy was performed to evaluate…