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Diagnose This!

Diagnose This 3/18/2024

What is at the top of your differential in a patient with a positive SPEP (IgG kappa) and the immunofluorescence…

Diagnose This!

Diagnose This 3/11/2024

What is your diagnosis in a patient with nephrotic syndrome? The electron photomicrograph demonstrates frequent subepithelial deposits along the glomerular…

Diagnose This!

Diagnose This 3/4/2024

The ultrastructural abnormalities present in the image are suspicious for what underlying disease?   The electron photomicrograph demonstrates two abnormal…


Neuro Notes

Denervated Schwann cell

Clinical History This 50-year-old previously healthy patient presented with a several year history of progressive numbness, tingling and distal lower…

Diagnose This!

Diagnose This 2/26/2024

What is your diagnosis based on the EM image provided? The electron microscopy image provided is that of portions of…

Neuro Notes

Regenerated Clusters

Clinical History This 60-year-old diabetic patient presented with complaints of bilateral chronic numbness and tingling involving their legs in a…


Diagnose This!

Diagnose This 2/19/2024

What is your leading diagnosis when seeing this particular IgG staining pattern?     Answer: Fibrillary Glomerulopathy The immunofluorescence shows…

Diagnose This!

Diagnose This 2/12/2024

What is your diagnosis?   The light microscopic image depicts a renal transplant biopsy with multiple histiocytes containing intracytoplasmic, targetoid…

Unusual Inflammatory Neuropathy
Neuro Notes

Unusual Inflammatory Neuropathy

Clinical History: This 60-year-old patient presented with a history of chronic progressive paresthesias involving all four extremities. Electrodiagnostic studies showed…


Diagnose This!

Diagnose This 2/5/2024

What is your diagnosis in this transplant biopsy given the features present?   Answer: Chronic active antibody-mediated rejection The features…

Neuro Notes

Vascular Micromineralization

Clinical History This 40-year-old female patient presented with a three month of bilateral medial thigh pain and edema. Her past…

Diagnose This!

Diagnose This 1/29/2024

What stain would you order to clinch the diagnosis in this transplant patient with AKI?   A CMV stain is…


Diagnose This!

Diagnosis This 1/15/2024

What considerations should be included in your differential diagnosis given the provided histologic finding? The image of a Jones silver…

Longstanding weakness
Neuro Notes

Longstanding Weakness in an Adult

Clinical History 54-year-old woman. Family history negative for neuromuscular disease Longstanding (L>R) upper & lower extremity weakness Periodic falls &…

Ischemic myopathy
Neuro Notes

Patient with Painful Leg

Clinical History The 60-year-old patient was admitted for complaints of acute left lower extremity pain and weakness, and was found…