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Diagnose This (November 23, 2020)

C3-dominant immune-complex, neutrophilic endocapillary hypercellularity, diagnose this, renal pathology, kidney biopsy, arkana laboratories
Based on the image provided, what would be your leading diagnosis with C3-dominant immune-complex deposition?       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​...

Arkana Holiday Tales: Dr. Boils

Today’s Arkana Holiday Tales episode features Dr. Boils and all things related to birthdays! Listen as she explains why birthdays are her favorite holiday and how to make a cake.   P.S.- Happy birthday Dr. Boils and Dr. Ambruzs!🎂🎈      

Macrophagic Myofasciitis (MMF)

Macrophagic Myofasciitis (MMF), neuro notes, arkana laboratories, neuropathology
This previously healthy pediatric patient presented with peculiar facial muscle hypertrophy, and genetic testing revealed one pathologic variant and two variants of uncertain significance (VUSs).  A muscle biopsy of the thigh was performed to further evaluate this patient.  Frozen sections and ultrastructural examination images of the inflammatory infiltrate are shown below.  What is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​...

Diagnose This (November 16, 2020)

glomerulomegaly, arkana laboratories, renal pathology, diagnose this, kidney pathology
  What conditions would be in your differential diagnosis for this finding? (Hint: large glomerulus)       ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​...

Twitter Poll (November 11, 2020)

NCAM-1, NCAM-1 associated membranous nephropathy, PLA2R, Twitter Poll, Arkana Laboratories
Answer: B In a recent article by Caza et al, NCAM-1 associated membranous nephropathy has been shown to be associated with systemic lupus erythematosus. Clinically, the article showed that the cases had a female predominance and were seen in younger patients than that typically seen in PLA2R or THSD7A-associated membranous nephropathy. In their cohort, NCAM-1-associated membranous made up approximately 7% of all membranous lupus nephritis cases (see reference).   Reference: Caza T, Hassen S, Kuperman M, et al (in press). Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis. Kid Int (2020) DOI: https://doi.org/10.1016/j.kint.2020.09.016.  

Other Uses For the Congo Red Stain

congo red stain, lipofuscin, neuro notes, arkana laboratories
Additional unintended useful information can be obtained from many histochemical stains used in the routine evaluation of skeletal muscle biopsies.  In addition to identifying amyloid deposition, Congo red stain provides some morphologic detail.  In this case, granular brown lipofuscin pigment can be seen in the atrophic muscle fibers under routine light microscopy.  The lipofuscin pigment is also autofluorescent, showing a white-yellow color under fluorescence microscopy. Congo Red stained frozen section of skeletal muscle under routine light microscopy (top) and fluorescence microscopy with FITC filter (bottom); original magnification: 400x each.  

Arkana Live – December 2020

december, Endocarditis-Related Glomerulonephritis, Infection-Related Glomerulonephritis, Light Microscopy, august, FSGS, september, october, July, Arkana Live, arkana laboratories
The next Arkana Live will be Saturday, December 19th at 11 am ET. Dr. Shree Sharma will be presenting on tubulointerstitial diseases. Register here: Arkana Live December 2020