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20th Anniversary Party

We're so thankful for vaccines that allow us to safely gather again. This past Saturday we celebrated our 20th anniversary with friends and family. Thanks to The Rail Yard for hosting us. A great time was had by all!  

Gonadotroph Adenoma

Gonadotroph Adenoma
The patient is an obese middle-aged male who presents with complaints of headaches, vision changes, and loss of libido. Neuroimaging reveals a 2 cm sellar mass. Endocrinology work-up shows no significant elevation in prolactin, ACTH, or growth hormone, and thyroid panel is within normal limits.  The decision was made to pursue endoscopic endonasal transsphenoidal resection of the pituitary macroadenoma.  Neuropathology microscopic examination shows a primary pituitary neoplasm arranged in a papillary growth pattern with patchy immunoreactivity for FSH greater than LH, and alpha subunit of the glycoprotein hormones (FSHα).      Using the images, which of the following pituitary gland...

Twitter Poll (May 13, 2021)

2,8-dihydroxyadeninuria (2,8-DHA) is caused by an autosomal recessive deficiency in the adenine phosphoribosyltransferase (APRT)
  Answer: 2,8-Dihydroxyadeninuria   2,8-dihydroxyadeninuria (2,8-DHA) is caused by an autosomal recessive deficiency in the adenine phosphoribosyltransferase (APRT). The gene is located on chromosome 16q24 of which greater than forty different mutations have been identified which include missense, nonsense, insertion, and deletion mutations. APRT is a purine salvage enzyme which in disease states leads to the absence of recycling adenine. Instead, adenine is eventually catabolized to 2,8-DHA which, in the kidney, leads to crystalline and stone formation due to its poor solubility in the urine. By light microscopy, these crystals are red to brown and birefringent on H&E and PAS...

Diagnose This (May 10, 2021)

juxtaglomerular apparatus hyperplasia in renal biopsy at Arkana Laboratories
What is your diagnosis for this finding in a young patient with renal artery stenosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​  ...

Diagnose This (May 3, 2021)

Serum Amyloid Protein (SAP) from renal biopsy at Arkana Laboratories
This image is from a biopsy of a young female who presented with proteinuria during pregnancy. Routine immunofluorescence was negative. What is this stain and what is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​...