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- Published: September 18, 2020
- By: Kelly Mrachek, M.D.
What histologic finding is observed in this case? Answer: Perifascicular Atrophy in Dermatomyositis This case shows an acquired inflammatory myopathy with well-developed perifascicular atrophy. Generally speaking, acquired inflammatory myopathies may be morphologically grouped into three categories: Polymyositis, Dermatomyositis, and Inclusion Body Myositis. The classification of acquired inflammatory myopathies has undergone recent refinement, and additional entities show characteristic morphologic and clinical features (see Pestronk reference). In the realm of acquired inflammatory myopathies, perifascicular atrophy is characteristic of dermatomyositis. The finding of skin rash in a characteristic distribution on physical exam is helpful, but is not always present (i.e. involvement...