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What histologic finding is observed in this case?     Answer:  Perifascicular Atrophy in Dermatomyositis   This case shows an acquired inflammatory myopathy with well-developed perifascicular atrophy.  Generally speaking, acquired inflammatory myopathies may be morphologically grouped into three categories: Polymyositis, Dermatomyositis, and Inclusion Body Myositis.  The classification of acquired inflammatory myopathies has undergone recent refinement, and additional entities show characteristic morphologic and clinical features (see Pestronk reference).  In the realm of acquired inflammatory myopathies, perifascicular atrophy is characteristic of dermatomyositis. The finding of skin rash in a characteristic distribution on physical exam is helpful, but is not always present (i.e. involvement...

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Introducing Neuro Notes!🚨   This new series by our neuropathologists, Dr. Wilson and Dr. Mrachek, will be highlighting cases, diagnosing neuropathological diseases, and making other observations in their unique neuropathology practice.   Below are ATPase enzyme histochemical stains from a skeletal muscle biopsy:   Image 1- pH 9.6 (Type II dark, Type I pale) Image 2- pH 4.6 (Type I dark, Type 2A pale, Type 2B intermediate) Image 3- pH 4.3 (Type I dark, Type II pale).  

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