African Americans have a much higher rate of non-diabetic end-stage renal disease (ESRD) than populations without recent African ancestry.
Shipping & Kit
Kidney failure occurs in Black Americans about three times as much as it does in white Americans. There are many reasons for this increased risk, including genetic changes known as “risk variants” in the APOL1 gene. Reasons to test for APOL1 genotyping include:
- Determining etiology of CKD in patients with possible African ancestry
- Determining risk status in patients with possible African ancestry
- Patient being considered for kidney donation
- Determination of carrier status in a family member
- Biopsy findings that suggest APOL1 risk alleles
No Cost to Patients APOL1 Genotyping Test Program
Arkana Laboratories and Vertex Pharmaceuticals are working together to increase awareness of APOL1-mediated kidney disease by making it possible for healthcare providers to order APOL1-risk variant testing at no cost in qualifying patients.
For more information on this program or to download the No Cost to Patients APOL1 Genotyping Test requisition form, click the links below.
This requisition form is for a routine APOL1 genotyping test.
|Samples must have two patient identifiers, preferably the patient’s name and date of birth
|Peripheral blood (preferred): At least 2ml in Lavender top (EDTA) tube Shipped overnight at room temperature
|Each sample must be accompanied by a requisition form with the declaration signed by the ordering provider
|Paraffin block or five unstained slides
|buccal swab: swab shipped overnight at room temperature in a DNA stabilization pouch/vial (e.g. isohelix rapiDri pouch)
- Histopathologic findings associated with APOL1 risk variants in chronic kidney disease
- Association of trypanolytic ApoL1 variants with kidney disease in African Americans
- APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy
- End-stage renal disease in African Americans with lupus nephritis is associated with APOL1
- Evolution of the primate trypanolytic factor APOL1