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Diagnose This 4/1/2024

By Joel Murphy, MD

Apr 02, 2024

What is this finding and what is the significance in the transplant setting?

Diagnose this, endothelialitis characterized by mononuclear cell inflammation


The light microscopic image depicts an artery with endothelialitis characterized by mononuclear cell inflammation under the arterial intima consistent with acute vascular rejection. Importantly, vascular rejection need not be seen in association with interstitial inflammation or tubulitis and for scoring purposes, the worst artery present (i.e. showing the most severe arteritis) dictates the overall v- score. Finally, vascular rejection can be seen not only in pure T-cell mediated rejection but can also be seen with acute antibody-mediated rejection.


Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.