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Archive: March 2020

Diagnose This (March 30,2020)

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What is the name of this rare finding typically seen in the outer medulla? ​   ​ ​   ​ ​   ​   ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​...

Twitter Poll (March 25, 2020)

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  ANSWER: True In 2018, Nickeleit et al. postulated a morphologic classification of polyomavirus nephropathy (PVN) based on pathologic features that correlate with clinical outcomes. The study defines 3 morphologic PVN classes using interstitial fibrosis and intra-renal PV load levels as statistically verified class denominators. It describes class 1 as an early PVN stage with favorable outcome, and classes 2 and 3 as having more pronounced impact on function with graft failure rates reaching 50% in class 3. The proposed PVN classification aims at improving clinico-pathologic correlation and the comparability of studies: a simple biopsy diagnosis of "PVN" no longer...

Twitter Poll (March 18, 2020)

ANSWER: B Membranous glomerulonephritis (MGN) is the most commonly described glomerular disease in IgG4-related disease. MGN was present in about 7% of cases of IgG4-related tubulointerstitial nephritis from two biopsy series studies.   Other specific glomerular diseases have been reported in patients with IgG4-related disease, including IgA nephropathy/Henoch Schönlein purpura nephritis, membranoproliferative glomerulonephritis (MPGN), and mesangioproliferative immune complex glomerulonephritis.   References: Alexander MP, et al. Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int 2013; 83:455-462. Saeki T, et al. Membranous nephropathy associated with IgG4-related systemic disease and without autoimmune pancreatitis. Clin Nephrol 2009; 71:173-178. Morimoto J, et al....

Diagnose This (March 16,2020)

What is your diagnosis?     ​ ​   ​   ​ ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​   ​ ​   ​ ​   ​ ​   ​ ​     ​   ​   ​ ​  ...

Fellowing Joel- Episode 19

Fellowing Joel, Joel Murphy, Renal Pathology
After a few weeks of travel and sickness, we finally got a chance to catch up with Dr. Murphy! [video width="1280" height="720" mp4="https://www.arkanalabs.com/wp-content/uploads/03/13/IMG_1387_3.mp4"][/video]