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Archive: September 2021

Dr. Rachelle Gietzen Finishes Her Renal Path Rotation

Dr. Rachelle Gietzen finishes her renal pathology rotation
Dr. Rachelle Gietzen has officially finished her renal path rotation at Arkana!   We were so thrilled to immerse her in the world of kidney pathology this past month. As the winner of the Arkana Renal Rotation Award, she’s headed home with a certificate of completion of her training, a cash award of $1000, and a gift of a renal pathology book. And of course, a new love of kidney pathology.   Interested in applying to our rotation? Find more info here - https://www.arkanalabs.com/education/renal-rotation/  

Intrafusal Muscle Fibers Muscle Fiber Spindle

intrafusal muscle fibers in the muscle fiber spindle
  The intrafusal muscle fibers also serve which of the following purposes? A. Force generation B. Maintain spindle tension C. Protein storage D. Protect nerves   Answer: Maintain spindle tension The intrafusal muscle fibers are innervated by gamma and beta motor neurons and contract or relax to maintain the sensitivity of the spindle. For example when the quadriceps muscle contracts and becomes shorter, the intrafusal muscle fibers take up slack in the spindle to maintain its sensitivity to stretch. The intrafusal muscle fibers do not contribute significantly to the force of the muscle contraction, store significant protein, or protect nerves....

Muscle Fiber Spindle

Muscle fiber spindle, nerve fibers
Toluidine blue-stained thick section prepared from glutaraldehyde-fixed EPON embedded tissue (400x original magnification) What of the following single choices regarding this structure is false? A. Generates contraction B. Senses muscle stretch C. Common in muscle D. Part of myotatic reflex   Answer: Generates contraction The muscle fiber spindle detects length and rate of muscle stretch, is the most frequently found sense organ in skeletal muscle, and is part of the deep tendon reflex (monosynaptic stretch reflex/myotatic reflex). It does not contribute significantly to the force of muscle contraction. References Banks RW. The innervation of the muscle spindle: a personal history....

MYMP Sighting

MYMP, kidney research, Nephrology Lagging Behind in Machine Learning Utilization
Our MYMP made a special appearance this week! Dr. Cassol (along with Dr. Sharma) recently published an article highlighting the underuse of machine learning as a research tool in the field of nephrology, titled Nephrology Lagging Behind in Machine Learning Utilization.   Read the paper here: https://www.kidney-international.org/article/S0085-2538(21)00734-1/fulltext 

Twitter Poll (September 9, 2021)

NELL1
  Which of the following membranous antigens has been recently identified and associated with underlying malignancy? A) NELL1 B) PLA2R C) EXT1/2 D) THSD7A   Answer: A) NELL1 NELL1, or neural epidermal growth factor-like 1 protein is a recently identified target antigen that has been associated with underlying malignancy in a subset of patients with membranous glomerulopathy. For further information, see references below. References: Caza T, Hassen S, Dvanajscak Z, Kuperman M, et al. NELL1 is a target antigen in malignancy-associated membranous nephropathy. Kidney Int 2020 Aug 20:S0085-2538(20)30956-X. Sethi S, Debiec H, Madden B, Charlesworth MC, et al. Neural epidermal...