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Monday History of MG Timeline of major discoveries in membranous glomerulopathy. Heymann nephritis was unique as a model of membranous glomerulopathy when it was reported in 1959 because it was the first to produce renal disease through autosensitization. http://pediatrics.aappublications.org/content/7/5/691 The antigenic target of Heymann nephritis (megalin) is largely absent from human podocytes but does have a role in human autoimmune disease as the antigenic target of anti-brush border antibody disease (LRP2-assoc nephropathy). https://jasn.asnjournals.org/content/29/2/644.long PLA2R was described as the major autoantigen of primary MG in 2009, approximately 50 years after the initial description of this form of glomerulonephritis. https://www.nejm.org/doi/full/10.1056/NEJMoa0810457 Tuesday...