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Diabetic Polyneuropathy

Diabetic Polyneuropathy, Hyaline thickening, neuro notes, arkana laboratories, muscle biopsy
This is an interesting common vascular finding in a sural nerve biopsy taken from an adult diabetic patient with paresthesias.  This photomicrograph shows hyaline thickening of an endoneurial blood vessel wall (black arrow, right of center) due to reduplication of perivascular basement membrane material and plump endothelial cells with associated narrowing of the vascular lumina.  These vascular changes are commonly seen in the setting of diabetic polyneuropathy and contribute to the myelinated axonal loss observed (i.e. axonopathic process) (toluidine blue stained thick section prepared from glutaraldehyde-fixed Epon resin-embedded tissue, 1000x oil immersion).

New Neuropathology Series: Neuro Notes

neuro notes, neuropathology, arkana laboratories
Introducing Neuro Notes!🚨   This new series by our neuropathologists, Dr. Wilson and Dr. Mrachek, will be highlighting cases, diagnosing neuropathological diseases, and making other observations in their unique neuropathology practice.   Below are ATPase enzyme histochemical stains from a skeletal muscle biopsy:   Image 1- pH 9.6 (Type II dark, Type I pale) Image 2- pH 4.6 (Type I dark, Type 2A pale, Type 2B intermediate) Image 3- pH 4.3 (Type I dark, Type II pale).