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- Published: February 13, 2020
- By: Vanessa Moreno, MD
Answer: C Transplant glomerulopathy (TG) is characterized by duplication of glomerular basement membrane (GBM) and is graded based on the percentage of glomerular capillary loops with GBM duplication or double contours in the most affected non-sclerotic glomerulus by LM. TG often indicates the presence of chronic antibody mediated rejection, for which there will be glomerulitis (B), C4d positivity in PTCs (C), and mesangial matrix increase (A). These findings are not in isolation from one another, therefore, "all of the above" would also be a correct answer. The Banff Lesion Score cg is based on the presence and extent of GBM double...