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Neuromuscular Junction Thick Section
Neuro Notes

Neuromuscular Junction Thick Section

This 60-year-old patient presented with muscle weakness and ptosis. Laboratory studies reported normal CPK and negative myositis autoantibody panel. Myasthenia…

Neuro Notes

Granulomata Cholesterol

This 70-year-old patient presented with a transient left sided weakness. Their past medical history included hypertension, hypothyroidism, and coronary artery…

denervation (neurogenic atrophy)
Neuro Notes


This 66-year-old patient presented with complaints of asymmetric distal lower extremity weakness. Their past medical history was significant for atrial…

vasculitis (“vasculitic myopathy”)
Neuro Notes

Vasculitic Myopathy

This 50-year-old patient presented with fever and bilateral leg myalgias. Laboratory studies showed elevated ESR (120) and normal CPK. On…

Small Unmyelinated Fibers Seen In Neurofilament Stain
Neuro Notes

Neurofilament Stain

This 35-year-old patient presented with complaints of numbness and tingling involving their feet, and distal lower extremity muscle weakness. Electrodiagnostic…

Oculopharyngeal Muscular Dystrophy
Neuro Notes

Intranuclear Inclusion

This 60-year-old patient initially presented with facial weakness, and subsequently developed ptosis and dysphonia. More recently they noticed difficulty rising…

Neuro Notes

Pacianian Corpuscle

A sural nerve biopsy was performed on this 60-year-old patient to evaluate for mononeuropathy.   What structure is demonstrated in…

combined COX/SDH stained frozen section 100x original magnification
Neuro Notes

Mitochondrial Abnormalities

The patient is a 35-year-old female who presents with complaints of fatigue. The patient’s past medical history is significant for…

demyelinating lesion and oligodendrocytes with intranuclear viral cytopathic change
Neuro Notes

Demyelinating Lesion

This 60-year-old immunocompromised patient presented with a one-week history of progressive right-sided weakness, difficulty concentrating, and impaired word finding ability.…

Neuro Notes

Neuromuscular Junction

Muscle biopsy was performed on this 40-year-old patient who presented with proximal lower extremity muscle weakness and normal CPK.  …

Toluidine blue showing NOTCH3
Neuro Notes

CADASIL and the NOTCH3 Gene

The patient is a 45-year-old patient with a history of migraines and several transient ischemic attacks. Their family history was…

nerve fibers in skin biopsy
Neuro Notes

Nerve Fibers In Skin Biopsy

This 30-year old patient presented with tingling and burning sensation to their feet and ankles. Electrodiagnostic studies (NCS) showed no…

Peripheral Nerve Axon with Microtubules
Neuro Notes

Peripheral Nerve Axon

This 60-year-old patient presented with complaints of a one-year history if intermittent pain and discomfort (burning and shooting) involving bilateral…

two small arteriole profiles within the perimysium which contain intravascular material
Neuro Notes

Intravascular Foreign Body Material

The patient is a 40-year-old who presented with proximal upper and lower extremity muscle weakness, and was found to have…

focal relatively circumscribed collection of mononuclear histiocytes with admixed chronic lymphoid inflammation
Neuro Notes

Granulomatous Myopathy and Neuropathy

This 40-year-old patient presented with a three year history of slowly progressive generalized muscle weakness. More recently their hands and…