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Neuro Notes

Unusual Dural Mass

This 50-year-old patient presented with complaints of headaches. MRI showed an extra-axial parasagittal dural based mass which was gross totally…

Neuro Notes

Intravascular lymphoma

This 70-year-old patient presented with confusion, weakness, and recent stroke-type symptoms. Brain MRI showed scattered contrast-enhancing white matter lesions involving…

Neuro Notes

Unusual Meningioma

This 50-year-old presented with progressively worsening headaches. MRI demonstrated a T2 hyperintense heterogeneously enhancing 2.5 cm lesion centered in the…


Neuro Notes

Intranuclear Amyloid-Like Inclusion

This 60-year-old patient presented with a several year history of slowly progressive proximal lower extremity weakness and mild elevation of…

Neuro Notes

Necrotic Myofibers

This 20-year-old patient presented with acute onset muscle weakness and numbness. Laboratory studies showed elevated CPK (4000) and negative toxin/drug…

Peripheral Nerve Fascicle
Neuro Notes

Peripheral Nerve Fascicle

This 50-year-old patient underwent muscle biopsy to evaluate for cramps and myalgias. What is the structure in the following figure?…


Neuro Notes

Sweat Gland Inclusions

This 13-year-old patient presented with relentlessly progressive treatment refractory myoclonic epilepsy. What are the inclusions seen in PASd stained sections…

Neuro Notes

Perifascicular Necrosis

This 60-year-old patient presented with progressive proximal upper and lower extremity muscle weakness of two months duration.   Which of…

Neuro Notes

Neuromuscular Junction Thick Section

This 60-year-old patient presented with muscle weakness and ptosis. Laboratory studies reported normal CPK and negative myositis autoantibody panel. Myasthenia…


Neuro Notes

Granulomata Cholesterol

This 70-year-old patient presented with a transient left sided weakness. Their past medical history included hypertension, hypothyroidism, and coronary artery…

denervation (neurogenic atrophy)
Neuro Notes

Denervation

This 66-year-old patient presented with complaints of asymmetric distal lower extremity weakness. Their past medical history was significant for atrial…

vasculitis (“vasculitic myopathy”)
Neuro Notes

Vasculitic Myopathy

This 50-year-old patient presented with fever and bilateral leg myalgias. Laboratory studies showed elevated ESR (120) and normal CPK. On…


Small Unmyelinated Fibers Seen In Neurofilament Stain
Neuro Notes

Neurofilament Stain

This 35-year-old patient presented with complaints of numbness and tingling involving their feet, and distal lower extremity muscle weakness. Electrodiagnostic…

Oculopharyngeal Muscular Dystrophy
Neuro Notes

Intranuclear Inclusion

This 60-year-old patient initially presented with facial weakness, and subsequently developed ptosis and dysphonia. More recently they noticed difficulty rising…

Neuro Notes

Pacianian Corpuscle

A sural nerve biopsy was performed on this 60-year-old patient to evaluate for mononeuropathy.   What structure is demonstrated in…