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Lupus Nephritis Class III/IV
Twitter Poll

Twitter Poll (January 4, 2018)

ANSWER: D Endocapillary hypercellularity, crescents, karyorrhexis and wire loops are some of the glomerular lesions seen in lupus nephritis class…

By Vanessa Moreno, MD
Immunotactoid Glomerulopathy
Twitter Poll

Twitter Poll (December 20, 2017)

ANSWER: D Immunotactoid glomerulopathy presents with Congo red-negative microtubular deposits with electron-lucent lumens measuring >30 nm in diameter.

By Vanessa Moreno, MD
Phospholipase A2 Receptor 1
Twitter Poll

Twitter Poll (December 14, 2017)

ANSWER: C Phospholipase A2 receptor 1 (PLA2R1) is present in podocytes and proximal tubules and has been detected in ~70%…

By Vanessa Moreno, MD

Levamisole/Cocaine DAV
Twitter Poll

Twitter Poll (December 6, 2017)

ANSWER: A Dual positivity for MPO and PR3 antibodies is a strong clue for levamisole/cocaine DAV.

By Vanessa Moreno, MD
HCV
Twitter Poll

Twitter Poll (November 30, 2017)

ANSWER: D Patients with HCV can present with membranoproliferative GN, Cryoglobulinemic GN, membranous GN, fibrillary GN, immunotactoid glomerulopathy and IgA…

By Vanessa Moreno, MD
polyomavirus nephritis
Twitter Poll

Twitter Poll (November 22, 2017)

ANSWER: C Immunohistochemistry for SV40 large-T antigen can detect BK and JC virus. It helps to diagnose polyomavirus nephritis; but…

By Vanessa Moreno, MD

Fabry Disease
Twitter Poll

Twitter Poll (November 15, 2017)

ANSWER: B Fabry disease causes a genetically derived deficiency in alpha-galactosidase A enzyme and accumulation of globotriaosylceramide (GL3).

By Vanessa Moreno, MD
Anti-GBM Glomerulonephritis
Twitter Poll

Twitter Poll (November 8, 2017)

ANSWER: B The characteristic immunofluorescence staining on Anti-GBM Glomerulonephritis is strong and linear IgG along glomerular basement membranes.

By Vanessa Moreno, MD
Hematuria
Twitter Poll

Twitter Poll (October 18, 2017)

Answer B is the best answer. Hematuria, while possible, is an uncommon presenting symptom of membranous glomerulopathy.

By Vanessa Moreno, MD

Collapsing glomerulopathy
Twitter Poll

Twitter Poll (October 4, 2017)

Answer: D Collapsing glomerulopathy has been associated with infection (HIV, parvovirus B19), drugs (INFs, BPs, CNIs) and APOL1-associated collapsing glomerulopathymutation…

By Vanessa Moreno, MD
Fraction of Glomeruli With Crescents
Twitter Poll

Twitter Poll (September 27, 2017)

B-The fraction of glomeruli w/ crescents is the sole discriminator between classes II through V. This system predicts the clinical…

By Vanessa Moreno, MD
Amyloid Fibril Deposits
Twitter Poll

Twitter Poll (September 12, 2017)

Answer: C Amyloid fibrils typically measure 8-12 nm (answer C). The deposits seen in Immunotactoid glomerulopathy are composed by tubules…

By Vanessa Moreno, MD