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Diagnose This (December 20, 2021)

Clarissa Cassol, MD renal pathologist at arkana laboratories
By Clarissa Cassol, MD

Dec 21, 2021

IgG, Anti-TBM Interstitial Nephritis

This is the biopsy of a 68-year-old female with a history of bone marrow transplant and AKI. What is your diagnosis?

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The biopsy shows acute interstitial nephritis with linear tubular basement membrane staining for IgG restricted to proximal tubules. These features are diagnostic of anti-TBM interstitial nephritis, a rare disease associated with autoantibodies to a non-collagenous 54-58 kD protein in proximal TBMs.


Additional Reading

AJKD Atlas of Renal Pathology: Anti–Tubular Basement Membrane Antibody Disease



Quick note: This post is to be used for informational purposes only and does not constitute medical or health advice. Each person should consult their own doctor with respect to matters referenced. Arkana Laboratories assumes no liability for actions taken in reliance upon the information contained herein.