©2016 All Rights Reserved.
Arkana Laboratories is a registered trademark.
Privacy and Terms

- Published: May 24, 2018
- By: Chris Larsen, MD
- Tags: 2, 8-DHA, Acute kidney injury, APRT, Chronic kidney disease, Crystalline nephropathy
The renal biopsy shown here has crystals present within the tubular lumens and cytoplasm with a brownish appearance by H&E (A) that are strongly silver positive on the Jones methenamine silver stain (B). The crystals are birefringent when viewed under polarized light (C). These findings are characteristic of 2,8 DHA crystal deposition in the kidney resulting from a deficiency of adenine phosphoribosyltransferase. 2,8 dihydroxyadeninuria is an autosomal recessive disease resulting from pathogenic variants in the APRT gene. It is an important disease to recognize as treatment with a low purine diet and allopurinol therapy blocks formation of 2,8 DHA and...